Academic Journal
Endogenous retroelement expression in the gut microenvironment of people living with HIV-1Research in context
| Title: | Endogenous retroelement expression in the gut microenvironment of people living with HIV-1Research in context |
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| Authors: | Nicholas Dopkins, Tongyi Fei, Stephanie Michael, Nicholas Liotta, Kejun Guo, Kaylee L. Mickens, Brad S. Barrett, Matthew L. Bendall, Stephanie M. Dillon, Cara C. Wilson, Mario L. Santiago, Douglas F. Nixon |
| Source: | EBioMedicine, Vol 103, Iss , Pp 105133- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | Human endogenous retrovirus (HERV), Interferons, Human immunodeficiency virus type I (HIV-I), Endogenous retroelement (ERE), Long interspersed nuclear element (LINE), Medicine, Medicine (General), R5-920 |
| More Details: | Summary: Background: Endogenous retroelements (EREs), including human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs), comprise almost half of the human genome. Our previous studies of the interferome in the gut suggest potential mechanisms regarding how IFNb may drive HIV-1 gut pathogenesis. As ERE activity is suggested to partake in type 1 immune responses and is incredibly sensitive to viral infections, we sought to elucidate underlying interactions between ERE expression and gut dynamics in people living with HIV-1 (PLWH). Methods: ERE expression profiles from bulk RNA sequencing of colon biopsies and PBMC were compared between a cohort of PLWH not on antiretroviral therapy (ART) and uninfected controls. Findings: 59 EREs were differentially expressed in the colon of PLWH when compared to uninfected controls (padj |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396424001683; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2024.105133 |
| Access URL: | https://doaj.org/article/77bd4000351b463188eba2fb539d30cc |
| Accession Number: | edsdoj.77bd4000351b463188eba2fb539d30cc |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2024.105133 |
| Published in: | EBioMedicine |
| Language: | English |