Bibliographic Details
| Title: |
Improving Bioaccessibility and Bioavailability of Isoflavone Aglycones from Chickpeas by Germination and Forming β-Cyclodextrin Inclusion Complexes |
| Authors: |
Yuanfan He, Jiani Xiang, Jie Chen, Sheng Fang, Zili Guo, Xianrui Liang |
| Source: |
Pharmaceutics, Vol 15, Iss 12, p 2684 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Pharmacy and materia medica |
| Subject Terms: |
chickpea isoflavones, cyclodextrin inclusion, pharmacokinetics, Pharmacy and materia medica, RS1-441 |
| More Details: |
Chickpea isoflavones have diverse pharmacological activities but with low water solubility and bioavailability. In this work, the isoflavone content in chickpeas was first increased by germination, and then the bioaccessibility and bioavailability of isoflavones in chickpea sprout extracts (CSE) were enhanced using β-cyclodextrin (β-CD) inclusion techniques. Firstly, the total content of isoflavones was increased by 182 times through sprouting, and isoflavones were presented mostly in the germ and radicle. Then, the chickpea sprout extract/β-cyclodextrin (CSE/β-CD) inclusion complex was prepared and characterized. The in vitro test showed that the cumulative release of two isoflavones, formononetin (FMN) and biochanin A (BCA), in the CSE/β-CD was significantly increased in a simulated digestive fluid. The in vivo rat pharmacokinetics demonstrated that the inclusion of FMN and BCA by β-CD effectively increased their bioavailability in rat plasma and tissues, especially in the liver. The study provides a feasible strategy for improving the bioavailability of isoflavones from chickpeas and is also beneficial to the utilization of other legume resources. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4923 |
| Relation: |
https://www.mdpi.com/1999-4923/15/12/2684; https://doaj.org/toc/1999-4923 |
| DOI: |
10.3390/pharmaceutics15122684 |
| Access URL: |
https://doaj.org/article/7789d77144f8431eb3a13ee0ae61ed71 |
| Accession Number: |
edsdoj.7789d77144f8431eb3a13ee0ae61ed71 |
| Database: |
Directory of Open Access Journals |
