Academic Journal
Immunotherapeutic effect of BCG-polysaccharide nucleic acid powder on Mycobacterium tuberculosis-infected mice using microneedle patches
| Title: | Immunotherapeutic effect of BCG-polysaccharide nucleic acid powder on Mycobacterium tuberculosis-infected mice using microneedle patches |
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| Authors: | Qinying Yan, Houming Liu, Zhigang Cheng, Yun Xue, Zhide Cheng, Xuyong Dai, Wanshui Shan, Fan Chen |
| Source: | Drug Delivery, Vol 24, Iss 1, Pp 1648-1653 (2017) |
| Publisher Information: | Taylor & Francis Group, 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Therapeutics. Pharmacology |
| Subject Terms: | immunotherapy, bcg-psn, tuberculosis, powder, microneedle patch, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Polysaccharide nucleic acid fractions of bacillus Calmette–Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunotherapeutic effects exist. Here, BCG-PSN powder was applied directly to the skin to evaluate the immunotherapeutic effects on mice infected with Mycobacterium tuberculosis (MTB). In total, 34 μg of BCG-PSN powder could be loaded into a microneedle patch (MNP). Mice receiving BCG-PSN powder delivered via MNP exhibited significantly increased IFN-γ and TNF-α production in peripheral blood CD4 + T cells and improved pathological changes in their lungs and spleens compared to control group mice. The immunotherapeutic effect of BCG-PSN powder delivered via MNP was better than that delivered via intramuscular injection to some extent. Furthermore, MNPs eliminate the side effects of syringes, and this study demonstrated that BCG-PSN can be clinically administrated in powder form. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1071-7544 1521-0464 10717544 |
| Relation: | https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464 |
| DOI: | 10.1080/10717544.2017.1391892 |
| Access URL: | https://doaj.org/article/7764091b86bc41368a7dd236ecd39e0b |
| Accession Number: | edsdoj.7764091b86bc41368a7dd236ecd39e0b |
| Database: | Directory of Open Access Journals |
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| ISSN: | 10717544 15210464 |
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| DOI: | 10.1080/10717544.2017.1391892 |
| Published in: | Drug Delivery |
| Language: | English |