Academic Journal
Comparing different boost concepts and beam configurations for proton therapy of pancreatic cancer
| Title: | Comparing different boost concepts and beam configurations for proton therapy of pancreatic cancer |
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| Authors: | Taiki Takaoka, Takeshi Yanagi, Shinsei Takahashi, Yuta Shibamoto, Yuto Imai, Dai Okazaki, Masanari Niwa, Akira Torii, Nozomi Kita, Seiya Takano, Natsuo Tomita, Akio Hiwatashi |
| Source: | Physics and Imaging in Radiation Oncology, Vol 30, Iss , Pp 100583- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Pancreatic cancer, Proton therapy, Pencil-beam scanning, Field-in-field, Simultaneous integrated boost, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Background and Purpose: Interfractional geometrical and anatomical variations impact the accuracy of proton therapy for pancreatic cancer. This study investigated field-in-field (FIF) and simultaneous integrated boost (SIB) concepts for scanned proton therapy treatment with different beam configurations. Materials and Methods: Robustly optimized treatment plans for fifteen patients were generated using FIF and SIB techniques with two, three, and four beams. The prescribed dose in 20 fractions was 60 Gy(RBE) for the internal gross tumor volume (IGTV) and 46 Gy(RBE) for the internal clinical target volume. Verification computed tomography (vCT) scans was performed on treatment days 1, 7, and 16. Initial treatment plans were recalculated on the rigidly registered vCTs. V100% and D95% for targets and D2cm3 for the stomach and duodenum were evaluated. Robustness evaluations (range uncertainty of 3.5 %) were performed to evaluate the stomach and duodenum dose-volume parameters. Results: For all techniques, IGTV V100% and D95% decreased significantly when recalculating the dose on vCTs (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-6316 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405631624000538; https://doaj.org/toc/2405-6316 |
| DOI: | 10.1016/j.phro.2024.100583 |
| Access URL: | https://doaj.org/article/76ddca99bafb4b688029aa758d46551d |
| Accession Number: | edsdoj.76ddca99bafb4b688029aa758d46551d |
| Database: | Directory of Open Access Journals |
| ISSN: | 24056316 |
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| DOI: | 10.1016/j.phro.2024.100583 |
| Published in: | Physics and Imaging in Radiation Oncology |
| Language: | English |