Iron and glutathione at the crossroad of redox metabolism in neurons

Bibliographic Details
Title:	Iron and glutathione at the crossroad of redox metabolism in neurons
Authors:	PAULA ARACENA, PABLA AGUIRRE, PABLO MUÑOZ, MARCO T NÚÑEZ
Source:	Biological Research, Vol 39, Iss 1, Pp 157-165 (2006)
Publisher Information:	BMC, 2006.
Publication Year:	2006
Collection:	LCC:Biology (General)
Subject Terms:	neurons, iron metabolism, iron accumulation, oxidative stress, glutathione metabolism, neurodegeneration, Biology (General), QH301-705.5
More Details:	Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	0716-9760 0717-6287
Relation:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017; https://doaj.org/toc/0716-9760; https://doaj.org/toc/0717-6287
Access URL:	https://doaj.org/article/a76d43e198904aaba11ecd3bf15ae6cd
Accession Number:	edsdoj.76d43e198904aaba11ecd3bf15ae6cd
Database:	Directory of Open Access Journals

More Details
ISSN:	07169760 07176287
Published in:	Biological Research
Language:	English