Bibliographic Details
| Title: |
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020 |
| Authors: |
Jessica Flood, Joseph Shingleton, Emma Bennett, Brodie Walker, Zahin Amin-Chowdhury, Godwin Oligbu, Jacob Avis, Richard M. Lynn, Peter Davis, Tara Bharucha, Clare E Pain, Deepthi Jyothish, Elizabeth Whittaker, Buvana Dwarakanathan, Rachael Wood, Christopher Williams, Olivia Swann, Malcolm G Semple, Mary E Ramsay, Christine E Jones, Athimalaipet V Ramanan, Nick Gent, Shamez N Ladhani |
| Source: |
The Lancet Regional Health. Europe, Vol 3, Iss , Pp 100075- (2021) |
| Publisher Information: |
Elsevier, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Public aspects of medicine |
| Subject Terms: |
Public aspects of medicine, RA1-1270 |
| More Details: |
Background: Paediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology and clinical characteristics of PIMS-TS in the United Kingdom and Ireland. Methods: Public Health England initiated prospective national surveillance of PIMS-TS through the British Paediatric Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD and TSS cases electronically and complete a detailed clinical questionnaire. Cases with symptom onset between 01 March and 15 June 2020 were included. Findings: There were 216 cases with features of PIMS-TS alone, 13 with features of both PIMS-TS and KD, 28 with features of PIMS-TS and TSS and 11 with features of PIMS-TS, KD and TSS, with differences in age, ethnicity, clinical presentation and disease severity between the phenotypic groups. There was a strong geographical and temporal association between SARS-CoV-2 infection rates and PIMS-TS cases. Of those tested, 14.8% (39/264) children had a positive SARS-CoV-2 RT-PCR, and 63.6% (75/118) were positive for SARS-CoV-2 antibodies. In total 44·0% (118/268) required intensive care, which was more common in cases with a TSS phenotype. Three of five children with cardiac arrest had TSS phenotype. Three children (1·1%) died. Interpretation: The strong association between SARS-CoV-2 infection and PIMS-TS emphasises the importance of maintaining low community infection rates to reduce the risk of this rare but severe complication in children and adolescents. Close follow-up will be important to monitor long-term complications in children with PIMS-TS. Funding: PHE. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2666-7762 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2666776221000521; https://doaj.org/toc/2666-7762 |
| DOI: |
10.1016/j.lanepe.2021.100075 |
| Access URL: |
https://doaj.org/article/76bb9b9eed994dcf97130ed3a0de86fe |
| Accession Number: |
edsdoj.76bb9b9eed994dcf97130ed3a0de86fe |
| Database: |
Directory of Open Access Journals |
