Academic Journal
Molecular characterization of SARS-CoV-2 Omicron clade and clinical presentation in children
| Title: | Molecular characterization of SARS-CoV-2 Omicron clade and clinical presentation in children |
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| Authors: | Rossana Scutari, Valeria Fox, Vanessa Fini, Annarita Granaglia, Anna Chiara Vittucci, Andrea Smarrazzo, Laura Lancella, Francesca Calo’ Carducci, Lorenza Romani, Laura Cursi, Paola Bernaschi, Cristina Russo, Andrea Campana, Stefania Bernardi, Alberto Villani, Carlo Federico Perno, Claudia Alteri |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | SARS-CoV-2 genomic evolution, Omicron clade, Minority variants, COVID-19 in children, Medicine, Science |
| More Details: | Abstract Since its emergence, SARS-CoV-2 Omicron clade has shown a marked degree of variability and different clinical presentation compared with previous clades. Here we demonstrate that at least four Omicron lineages circulated in children since December 2021, and studied until November 2022: BA.1 (33.6%), BA.2 (40.6%), BA.5 (23.7%) and BQ.1 (2.1%). At least 70% of infections concerned children under 1 year, most of them being infected with BA.2 lineages (n = 201, 75.6%). Looking at SARS-CoV-2 genetic variability, 69 SNPs were found to be significantly associated in pairs, (phi 0.3 and p-value 0.75). One of these clusters (A23040G, A27259C, T23617G, T23620G) was also positively associated with moderate/severe COVID-19 presentation (AOR [95% CI] 2.49 [1.26–4.89] p-value: 0.008) together with comorbidities (AOR [95% CI] 2.67 [1.36–5.24] p-value: 0.004). Overall, these results highlight the extensive SARS-CoV-2 Omicron circulation in children, mostly aged |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-55599-0 |
| Access URL: | https://doaj.org/article/76ab070bc36d4657bd8d15dcec8bb83a |
| Accession Number: | edsdoj.76ab070bc36d4657bd8d15dcec8bb83a |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-55599-0 |
| Published in: | Scientific Reports |
| Language: | English |