Bibliographic Details
| Title: |
Cord blood myostatin concentrations by gestational diabetes mellitus and fetal sex |
| Authors: |
Rong Huang, Mark Kibschull, Laurent Briollais, Zdenka Pausova, Kellie Murphy, John Kingdom, Stephen Lye, Zhong-Cheng Luo |
| Source: |
Frontiers in Endocrinology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
gestational diabetes mellitus, myostatin, testosterone, insulin-like growth factor, sex difference, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
IntroductionMyostatin is a member of the transforming growth factor β superfamily, and is mainly secreted from skeletal muscle. Animal studies have demonstrated that deficiency in myostatin promotes muscle growth and protects against insulin resistance. In humans, gestational diabetes mellitus (GDM) affects fetal insulin sensitivity. Females are more insulin resistant and weigh less than males at birth. We sought to assess whether cord blood myostatin concentrations vary by GDM and fetal sex, and the associations with fetal growth factors.MethodsIn a study of 44 GDM and 66 euglycemic mother-newborn dyads, myostatin, insulin, proinsulin, insulin-like growth factor (IGF)-1, IGF-2 and testosterone were measured in cord blood samples.ResultsCord blood myostatin concentrations were similar in GDM vs. euglycemic pregnancies (mean ± SD: 5.5 ± 1.4 vs. 5.8 ± 1.4 ng/mL, P=0.28), and were higher in males vs. females (6.1 ± 1.6 vs. 5.3 ± 1.0 ng/mL, P=0.006). Adjusting for gestational age, myostatin was negatively correlated with IGF-2 (r=-0.23, P=0.02), but not correlated with IGF-1 (P=0.60) or birth weight (P=0.23). Myostatin was strongly correlated with testosterone in males (r=0.56, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2023.1018779/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2023.1018779 |
| Access URL: |
https://doaj.org/article/76552f1e1039474a83eacd2252c510f0 |
| Accession Number: |
edsdoj.76552f1e1039474a83eacd2252c510f0 |
| Database: |
Directory of Open Access Journals |
