| Title: |
Comprehensive chemical profiling of Bassia indica Wight. aerial parts extract using UPLC-ESI–MS/MS, and its antiparasitic activity in Trichinella spiralis infected mice: in silico supported in vivo study |
| Authors: |
Magdy M. D. Mohammed, Elham A. Heikal, Fatma M. Ellessy, Tarek Aboushousha, Mosad A. Ghareeb |
| Source: |
BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-22 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Other systems of medicine |
| Subject Terms: |
Bassia indica, Chenopodiaceae, Trichinella spiralis, Saponins, Phenolics, Molecular Docking, Other systems of medicine, RZ201-999 |
| More Details: |
Abstract Background Trichinellosis is a public health threat infected both animals and humans as a result of eating undercooked meat. It caused by Trichinella spiralis that has widespread drug resistance and even developed many sophisticated strategies for their survival, this increases the demand in searching for new anthelmintic drugs from natural source. Methods Our objectives were to test the in vitro and in vivo anthelmintic activity of Bassia indica BuOH frac., and to characterize its chemical composition using UPLC-ESI–MS/MS. Besides an in silico molecular docking study with the prediction of the PreADMET properties. Results In vitro investigation of B. indica BuOH frac., showed severe destruction of the adult worm and larvae, marked cuticle swelling, areas with vesicles, blebs and loss of annulations. This was assured via in vivo study, which revealed a significant reduction (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2662-7671 |
| Relation: |
https://doaj.org/toc/2662-7671 |
| DOI: |
10.1186/s12906-023-03988-9 |
| Access URL: |
https://doaj.org/article/76044eaa3f784646b541399c817cd6a8 |
| Accession Number: |
edsdoj.76044eaa3f784646b541399c817cd6a8 |
| Database: |
Directory of Open Access Journals |
