A bioinformatics study concerning structural and functional properties of human caveolin proteins
| Title: | A bioinformatics study concerning structural and functional properties of human caveolin proteins |
|---|---|
| Authors: | Isvoran Adriana, Craciun Dana, Ciorsac Alecu, Perrot Nahuel, Beswick Veronica, Nedellec Pierre, Sanson Alain, Jamin Nadege |
| Source: | Journal of the Serbian Chemical Society, Vol 79, Iss 2, Pp 133-150 (2014) |
| Publisher Information: | Serbian Chemical Society, 2014. |
| Publication Year: | 2014 |
| Collection: | LCC:Chemistry |
| Subject Terms: | secondary structure, disordered regions, functional domains, Chemistry, QD1-999 |
| More Details: | We performed a bioinformatics study to predict and compare the structural and functional properties of human caveolins: caveolin-1, -2 and -3. The computed local physico-chemical properties, predictions of their secondary structure elements and interacting partners of caveolin-2 and -3 are compared to experimentally proved structural and functional properties of caveolin-1. These data combined with the sequences alignment of the three caveolins, allowed predicting and characterizing the functional domains of caveolin-2 and -3. The hydrophobic regions of these proteins are highly similar in sequences and physicochemical properties and it is in good agreement with their known membrane locations and functions. The most divergent in sequences and properties are the C-terminal regions of caveolins suggesting that they might be responsible for their distinct predicted interactions, with direct consequences on signalling processes. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0352-5139 1820-7421 13071610 |
| Relation: | https://doaj.org/toc/0352-5139; https://doaj.org/toc/1820-7421 |
| DOI: | 10.2298/JSC130716100I |
| Access URL: | https://doaj.org/article/75cd119691f942a9bc90bff373e08871 |
| Accession Number: | edsdoj.75cd119691f942a9bc90bff373e08871 |
| Database: | Directory of Open Access Journals |
| ISSN: | 03525139 18207421 13071610 |
|---|---|
| DOI: | 10.2298/JSC130716100I |
| Published in: | Journal of the Serbian Chemical Society |
| Language: | English |