Binding of Perfluoroalkyl Substances to Nanoplastic Protein Corona Is pH‐Dependent and Attenuates Their Bioavailability and Toxicity

Bibliographic Details
Title: Binding of Perfluoroalkyl Substances to Nanoplastic Protein Corona Is pH‐Dependent and Attenuates Their Bioavailability and Toxicity
Authors: Zongshan Zhao, Jiaqiang Yao, Haimei Li, Jing Lan, Yan Bao, Lining Zhao, Wansong Zong, Yanmin Long, Lei Feng, Henner Hollert, Xingchen Zhao
Source: Small Science, Vol 4, Iss 12, Pp n/a-n/a (2024)
Publisher Information: Wiley-VCH, 2024.
Publication Year: 2024
Collection: LCC:Materials of engineering and construction. Mechanics of materials
Subject Terms: cellular toxicity, nanoplastics, polyfluoroalkyl substances, protein, ternary interaction, Materials of engineering and construction. Mechanics of materials, TA401-492
More Details: There is a severe lack of understanding of the effects of micro/nanoplastics on human proteins and cells, especially in the presence of organic pollutants. Herein, both in vivo and in vitro assays are conducted to structurally evaluate blood protein complexed with perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) as well as their coronas formed on polystyrene nanoplastics (PNs). PFOS is bound to serum albumin (SA) about 4 times as firmly as PFOA, which is not influenced by protein corona formation onto PN surfaces. However, the small molecular binding dramatically suppresses SA–PN aggregation. Low pH weakens the protein interaction of PFOS while not PFOA, which is also independent of PN adsorption, but the interaction with SA is still stronger for PFOS than PFOA, indicating higher serum persistence and risks. The presence of PN suppresses the cellular uptake of the chemicals and attenuates cytotoxicity due to low bioavailability. Overall, these results provide fundamental information on the ternary interaction mode of protein, particle, and organic pollutants in physiological environments with varying pH, as well as the subsequent cellular responses.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2688-4046
Relation: https://doaj.org/toc/2688-4046
DOI: 10.1002/smsc.202400255
Access URL: https://doaj.org/article/759a9603c4a04c8890210148d6bb6dcb
Accession Number: edsdoj.759a9603c4a04c8890210148d6bb6dcb
Database: Directory of Open Access Journals
More Details
ISSN:26884046
DOI:10.1002/smsc.202400255
Published in:Small Science
Language:English