Academic Journal
A novel methodology utilizing microchip implants to monitor individual activity and body temperature for assessing knee pain in group-housed rats
| Title: | A novel methodology utilizing microchip implants to monitor individual activity and body temperature for assessing knee pain in group-housed rats |
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| Authors: | Shoichi Hasegawa, Riko Yamashita, Yusuke Nakagawa, Kazumasa Miyatake, Hiroki Katagiri, Tomomasa Nakamura, Hideyuki Koga, Ichiro Sekiya, Toshitaka Yoshii, Vicki Rosen, Kunikazu Tsuji |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract The pain assessment in animals is challenging as they cannot verbally express the site and severity of pain. In this study, we tried a small implantable actimeter, “Nanotag”, to monitor spontaneous locomotor activity and body temperature in animals suffering from a chemical-induced rat knee arthritis as compared to naïve and steroid-treated rats. Nanotag could detect the decrease in locomotor activity quickly after the arthritis induction and anti-inflammation analgesic treatment by intra-articular injection of steroid significantly improved locomotor activity. These changes were in the same line with those of a conventional knee pain evaluation method (incapacitance test). Nanotag can be utilized as the non-interventional, continuous, and completely objective monitoring the amount of pain in rat knee arthritis model. This traditional yet innovative method may be universally applicable to various pain models and species, making it a worthwhile device for research across diverse fields. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-67024-7 |
| Access URL: | https://doaj.org/article/758fbb122a764f359b148216a8848f73 |
| Accession Number: | edsdoj.758fbb122a764f359b148216a8848f73 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-67024-7 |
| Published in: | Scientific Reports |
| Language: | English |