Bibliographic Details
| Title: |
A human fetal cerebellar map of the late second trimester reveals developmental molecular characteristics and abnormality in trisomy 21 |
| Authors: |
Hongmin Yu, Yun Liu, Fanqing Xu, Yuanyuan Fu, Ming Yang, Ling Ding, Yixuan Wu, Fuchou Tang, Jie Qiao, Lu Wen |
| Source: |
Cell Reports, Vol 43, Iss 8, Pp 114586- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
CP: Neuroscience, CP: Genomics, Biology (General), QH301-705.5 |
| More Details: |
Summary: Our understanding of human fetal cerebellum development during the late second trimester, a critical period for the generation of astrocytes, oligodendrocytes, and unipolar brush cells (UBCs), remains limited. Here, we performed single-cell RNA sequencing (scRNA-seq) in human fetal cerebellum samples from gestational weeks (GWs) 18–25. We find that proliferating UBC progenitors distribute in the subventricular zone of the rhombic lip (RLSVZ) near white matter (WM), forming a layer structure. We also delineate two trajectories from astrogenic radial glia (ARGs) to Bergmann glial progenitors (BGPs) and recognize oligodendrogenic radial glia (ORGs) as one source of primitive oligodendrocyte progenitor cells (PriOPCs). Additionally, our scRNA-seq analysis of the trisomy 21 fetal cerebellum at this stage reveals abnormal upregulated genes in pathways such as the cell adhesion pathway and focal adhesion pathway, which potentially promote neuronal differentiation. Overall, our research provides valuable insights into normal and abnormal development of the human fetal cerebellum. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S221112472400915X; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2024.114586 |
| Access URL: |
https://doaj.org/article/757c32592fb347468065371cdee568ad |
| Accession Number: |
edsdoj.757c32592fb347468065371cdee568ad |
| Database: |
Directory of Open Access Journals |
