Bibliographic Details
| Title: |
Primary Aldosteronism and Bone Metabolism: A Systematic Review and Meta-Analysis |
| Authors: |
Shaomin Shi, Chunyan Lu, Haoming Tian, Yan Ren, Tao Chen |
| Source: |
Frontiers in Endocrinology, Vol 11 (2020) |
| Publisher Information: |
Frontiers Media S.A., 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
primary aldosteronism, osteoporosis, bone metabolism, fracture, systematic review, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
BackgroundCurrently, increasing evidence shows that excess aldosterone may have an impact on bone health, and primary aldosteronism (PA) may be a secondary cause of osteoporosis. This problem is worthy of attention because secondary osteoporosis is always potentially reversible, which affects the selection of treatment for PA to some extent. The present systematic review will assess and summarize the available data regarding the relationship between PA and osteoporosis.MethodsPubmed and Embase were searched for clinical trials related to the association between PA and bone metabolism. The results were limited to full-text articles published in English, without restrictions for the publication time. The quality of clinical trials was appraised, and the data were extracted. Biochemical parameters of bone turnover in PA patients were assessed using random-effect meta-analysis. Descriptive analysis was performed for other parameters, for data is insufficient.ResultsA final total of 15 articles were included in this review. The meta-analysis of six studies showed that subjects with PA had higher serum PTH levels (MD=21.50 pg/ml, 95% CI (15.63, 27.37), P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fendo.2020.574151/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2020.574151 |
| Access URL: |
https://doaj.org/article/75689f7f41804190a71bc991c519f0b7 |
| Accession Number: |
edsdoj.75689f7f41804190a71bc991c519f0b7 |
| Database: |
Directory of Open Access Journals |
