Bibliographic Details
| Title: |
The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation |
| Authors: |
Bing Liu, Oscar C. Salgado, Sangya Singh, Keli L. Hippen, Jason C. Maynard, Alma L. Burlingame, Lauren E. Ball, Bruce R. Blazar, Michael A. Farrar, Kristin A. Hogquist, Hai-Bin Ruan |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-specific deficiency of OGT leading to severe autoimmunity. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-08300-3 |
| Access URL: |
https://doaj.org/article/753e12c8c75848d7bf15336570926002 |
| Accession Number: |
edsdoj.753e12c8c75848d7bf15336570926002 |
| Database: |
Directory of Open Access Journals |
