Bibliographic Details
| Title: |
Upregulated anti-angiogenic miR-424-5p in type 1 diabetes (model of subclinical cardiovascular disease) correlates with endothelial progenitor cells, CXCR1/2 and other parameters of vascular health |
| Authors: |
Alice Tamara, David J. Coulson, Jevi Septyani Latief, Sherin Bakhashab, Jolanta U. Weaver |
| Source: |
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Medicine (General)
LCC:Biochemistry |
| Subject Terms: |
MiR-424-5p, IL8, CD45dimCD34+CD133+, CXCR1/2, T1DM, Medicine (General), R5-920, Biochemistry, QD415-436 |
| More Details: |
Abstract Background In spite of clinical progress, cardiovascular disease (CVD) remains the predominant cause of mortality worldwide. Overexpression studies in animals have proven miR-424-5p to have anti-angiogenic properties. As type 1 diabetes mellitus (T1DM) without CVD displays endothelial dysfunction and reduced circulating endothelial progenitor cells (cEPCs), it offers a model of subclinical CVD. Therefore, we explored miR-424-5p, cytokines and vascular health in T1DM. Methods Twenty-nine well-controlled T1DM patients with no CVD and 20-matched controls were studied. Cytokines IL8, TNF-α, IL7, VEGF-C, cEPCs/CD45dimCD34+CD133+ cells and ex-vivo proangiogenic cells (PACs)/fibronectin adhesion assay (FAA) were measured. MiR-424-5p in plasma and peripheral blood mononuclear cells (PBMC) along with mRNAs in PBMC was evaluated. Results We found an elevation of IL7 (p = 0.008), IL8 (p = 0.003), TNF-α (p = 0.041), VEGF-C (p = 0.013), upregulation of mRNA CXCR1 (p = 0.009), CXCR2 (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1757-6512 |
| Relation: |
https://doaj.org/toc/1757-6512 |
| DOI: |
10.1186/s13287-021-02332-7 |
| Access URL: |
https://doaj.org/article/75373b152ef8406faf625e47b6edd4d9 |
| Accession Number: |
edsdoj.75373b152ef8406faf625e47b6edd4d9 |
| Database: |
Directory of Open Access Journals |
