Bibliographic Details
| Title: |
The Dual Role of miR-186 in Cancers: Oncomir Battling With Tumor Suppressor miRNA |
| Authors: |
Ying Xiang, Qing Tian, Li Guan, Shuai-shuai Niu |
| Source: |
Frontiers in Oncology, Vol 10 (2020) |
| Publisher Information: |
Frontiers Media S.A., 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
miRNA, cancer, oncomir, tumor suppressor miRNA, dual role, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
MicroRNAs (miRNAs) are a class of small non-coding RNAs which regulate gene expression at post-transcriptional level. Alterations of miR-186 expression were demonstrated in numerous cancers, shown to play a vital role in oncogenesis, invasion, metastasis, apoptosis, and drug resistance. MiR-186 was documented as a tumor suppressor miRNA in the majority of studies, while conflicting reports verified miR-186 as an oncomir. The contradictory role in cancers may impede the application of miR-186, as well as other dual-functional miRNAs, as a diagnostic and therapeutic target. This review emphasizes the alterations and functions of miR-186 in cancers and discusses the mechanisms behind the contradictory findings. Among these, target abundance and dose-dependent effects of miR-186 are highlighted. The paper aims to review the challenges involved in developing diagnostic and therapeutic strategies for cancer treatment based on dual-functional miRNAs. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/article/10.3389/fonc.2020.00233/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2020.00233 |
| Access URL: |
https://doaj.org/article/74a09672f7fb45db8e06493f9f103b5f |
| Accession Number: |
edsdoj.74a09672f7fb45db8e06493f9f103b5f |
| Database: |
Directory of Open Access Journals |
