Bibliographic Details
| Title: |
Tocilizumab in treatment-naïve patients with Takayasu arteritis: TOCITAKA French prospective multicenter open-labeled trial |
| Authors: |
Arsene Mekinian, David Saadoun, Eric Vicaut, Sara Thietart, Bertrand Lioger, Patrick Jego, Alexandre Bleibtreu, Nicolas Limal, Jerome Connault, Jacques-Eric Gottenberg, Pauline Lhorte, Jean Pierre Bertola, Juliette Delforge, Nicole Ferreira-Maldent, Antoinette Perlat, Zohra Talib, Matthieu Vautier, Léa Savey, Isabelle Quiere, Patrice Cacoub, Olivier Fain, for the French Takayasu network |
| Source: |
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-7 (2020) |
| Publisher Information: |
BMC, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Diseases of the musculoskeletal system |
| Subject Terms: |
Takayasu arteritis, Tocilizumab, Vasculitis treatment, Diseases of the musculoskeletal system, RC925-935 |
| More Details: |
Abstract Objectives To assess long-term efficacy of tocilizumab in treatment-naive patients with Takayasu arteritis (TAK). Methods Prospective open-labeled trial in naïve patients with TAK who received steroids at the dose of 0.7 mg/kg/day and 7 infusions of 8 mg/kg/month of tocilizumab. The primary endpoint was the number of patients who discontinued steroids after 7 infusions of tocilizumab. Secondary endpoints included disease activity and the number of relapses during 18-month follow-up. Results Thirteen patients with TAK were included, with a median age of 32 years [19–45] and 12 (92%) females. Six (54%) patients met the primary end-point. A significant decrease of disease activity was observed after 6 months of tocilizumab therapy: decrease of median NIH scale (3 [3, 4] at baseline, versus 1 [0–2] after 6 months; p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1478-6362 |
| Relation: |
http://link.springer.com/article/10.1186/s13075-020-02311-y; https://doaj.org/toc/1478-6362 |
| DOI: |
10.1186/s13075-020-02311-y |
| Access URL: |
https://doaj.org/article/749b57ae211149ac81d0ddd3dbfafe91 |
| Accession Number: |
edsdoj.749b57ae211149ac81d0ddd3dbfafe91 |
| Database: |
Directory of Open Access Journals |
