Bibliographic Details
| Title: |
Switching to coformulated bictegravir, emtricitabine, and tenofovir alafenamide maintained viral suppression in adults with historical virological failures and K65N/R mutation |
| Authors: |
Mao-Song Tsai, Hsin-Yun Sun, Cheng-Pin Chen, Chen-Hsiang Lee, Chun-Yuan Lee, Chun-Eng Liu, Hung-Jen Tang, Tung-Che Hung, Chia-Wen Li, Yuan-Ti Lee, Bo-Huang Liou, Chia-Jui Yang, Chien-Ching Hung |
| Source: |
International Journal of Infectious Diseases, Vol 126, Iss , Pp 39-47 (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Viral rebound, Low-level viremia, Integrase strand-transfer inhibitor, Nucleoside reverse-transcriptase inhibitor, Resistance-associated mutation, Genetic barrier, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Objectives: Real-world experience with coformulated bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF) is sparse as a switch regimen among people living with HIV (PLWH) having achieved viral suppression after previous virologic failures with the emergence of K65N/R. Methods: In this retrospective study, PLWH aged ≥20 years who had previous virologic failures with emergent K65N/R were included for switching to BIC/FTC/TAF after having achieved plasma HIV RNA load (PVL) 50 copies/ml) at week 48 using a modified US Food and Drug Administration snapshot algorithm. Results: A total of 72 PLWH with K65N/R who switched to BIC/FTC/TAF were identified. A total of 42 (59.7%) had concurrent M184V/I, and 9 (12.5%) had ≥1 thymidine analog mutations. The median duration of viral suppression was 4.7 years (interquartile range 2.3-5.8), and 97.2% (n = 70) had PVL |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1201971222005975; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2022.11.012 |
| Access URL: |
https://doaj.org/article/74974abe7a07487f88a22c95815bc8ae |
| Accession Number: |
edsdoj.74974abe7a07487f88a22c95815bc8ae |
| Database: |
Directory of Open Access Journals |
