Metabolomic analysis of vascular cognitive impairment due to hepatocellular carcinoma

Bibliographic Details
Title: Metabolomic analysis of vascular cognitive impairment due to hepatocellular carcinoma
Authors: Dan Zhu, Yamei Zhu, Lin Liu, Xiaoxue He, Shizhong Fu
Source: Frontiers in Neurology, Vol 13 (2023)
Publisher Information: Frontiers Media S.A., 2023.
Publication Year: 2023
Collection: LCC:Neurology. Diseases of the nervous system
Subject Terms: metabolomics, metabolic DEGs, prognostic model, biomarkers, neurovascular disease, hepatocellular carcinoma (HCC), Neurology. Diseases of the nervous system, RC346-429
More Details: IntroductionScreening for metabolically relevant differentially expressed genes (DEGs) shared by hepatocellular carcinoma (HCC) and vascular cognitive impairment (VCI) to explore the possible mechanisms of HCC-induced VCI.MethodsBased on metabolomic and gene expression data for HCC and VCI, 14 genes were identified as being associated with changes in HCC metabolites, and 71 genes were associated with changes in VCI metabolites. Multi-omics analysis was used to screen 360 DEGs associated with HCC metabolism and 63 DEGs associated with VCI metabolism.ResultsAccording to the Cancer Genome Atlas (TCGA) database, 882 HCC-associated DEGs were identified and 343 VCI-associated DEGs were identified. Eight genes were found at the intersection of these two gene sets: NNMT, PHGDH, NR1I2, CYP2J2, PON1, APOC2, CCL2, and SOCS3. The HCC metabolomics prognostic model was constructed and proved to have a good prognostic effect. The HCC metabolomics prognostic model was constructed and proved to have a good prognostic effect. Following principal component analyses (PCA), functional enrichment analyses, immune function analyses, and TMB analyses, these eight DEGs were identified as possibly affecting HCC-induced VCI and the immune microenvironment. As well as gene expression and gene set enrichment analyses (GSEA), a potential drug screen was conducted to investigate the possible mechanisms involved in HCC-induced VCI. The drug screening revealed the potential clinical efficacy of A-443654, A-770041, AP-24534, BI-2536, BMS- 509744, CGP-60474, and CGP-082996.ConclusionHCC-associated metabolic DEGs may influence the development of VCI in HCC patients.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-2295
Relation: https://www.frontiersin.org/articles/10.3389/fneur.2022.1109019/full; https://doaj.org/toc/1664-2295
DOI: 10.3389/fneur.2022.1109019
Access URL: https://doaj.org/article/741ed2405935415fb110fbc6d1d828f9
Accession Number: edsdoj.741ed2405935415fb110fbc6d1d828f9
Database: Directory of Open Access Journals
More Details
ISSN:16642295
DOI:10.3389/fneur.2022.1109019
Published in:Frontiers in Neurology
Language:English