Bibliographic Details
| Title: |
Predictive Value of Thyroglobulin Changes for the Curative Effect of Radioiodine Therapy in Patients With Metastatic Differentiated Thyroid Carcinoma |
| Authors: |
Congcong Wang, Ruiguo Zhang, Renfei Wang, Zhaowei Meng, Guizhi Zhang, Feng Dong, Yajing He, Jian Tan |
| Source: |
Frontiers in Endocrinology, Vol 12 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
differentiated thyroid carcinoma, radioiodine therapy, iodine radioisotope, curative effect, metastatic lesion, thyroglobulin change, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
BackgroundSerum thyroglobulin (Tg) serves as a sensitive and easily available tumor marker for patients with metastatic differentiated thyroid carcinoma (m-DTC). The aim of the present study was to evaluate the predictive value of suppressed Tg changes (Δsup-Tg) and/or stimulated Tg changes (Δsti-Tg) to evaluate the efficacy of radioiodine therapy (RT).MethodsWe studied 117 patients with m-DTC who received RT. Δsup-Tg and Δsti-Tg were compared after the first RT in different therapeutic response groups and a receiver-operating characteristic (ROC) curve was used to determine the cut-off values to predict non-remission. Univariate and multivariate analyses were used to investigate the effects of 17 observed factors on the efficacy of RT.ResultsA total of 218 RT events in 117 patients with m-DTC were analyzed. After the last RT, the remission rate was 70.94% (83/117), and the proportion of remission events accounted for 74.77% (163/218). ROC curve analysis showed that the cut-off values for Δsup-Tg and Δsti-Tg after the first RT to predict the non-remission of RT were 21.54% and 27.63%, respectively. Age, the size of the metastasis, the maximum count of target metastatic lesions and the average count of contralateral non-target tissue on tomographic imaging (Tmax/NTmean) of the first RT, and Δsup-Tg after the first RT were identified as independent factors associated with RT efficacy.ConclusionsTg response was valuable to predict RT efficacy for patients with m-DTC. Age, the size of the metastasis, Tmax/NTmean, and Δsup-Tg after the first RT were verified as independent predictive factors of RT efficacy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2021.667544/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2021.667544 |
| Access URL: |
https://doaj.org/article/aa73fd628acd49fbb90518f661d98a64 |
| Accession Number: |
edsdoj.73fd628acd49fbb90518f661d98a64 |
| Database: |
Directory of Open Access Journals |
