Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells
| Title: | Long-Term Remission of Primary Bone Marrow Diffuse Large B-Cell Lymphoma Treated with High-Dose Chemotherapy Rescued by In Vivo Rituximab-Purged Autologous Stem Cells |
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| Authors: | Hiroshi Kazama, Masanao Teramura, Kentaro Yoshinaga, Akihiro Masuda, Toshiko Motoji |
| Source: | Case Reports in Medicine, Vol 2012 (2012) |
| Publisher Information: | Hindawi Limited, 2012. |
| Publication Year: | 2012 |
| Collection: | LCC:Medicine |
| Subject Terms: | Medicine |
| More Details: | Primary bone marrow diffuse large B-cell lymphoma (DLBCL) is a rare type of extranodal lymphoma with poor prognosis. Here, we report a case of primary bone marrow DLBCL successfully treated with high-dose chemotherapy and rescued by in vivo rituximab-purged autologous stem cells. A 39-year-old woman visited our hospital because of anemia. Bone marrow examination revealed a large B-cell lymphoma invasion. An 18F-fluorodeoxyglucose positron emission tomography scan revealed disseminated bone marrow uptake without evidence of dissemination at other sites. These findings led to a diagnosis of primary bone marrow DLBCL. Our patient underwent R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy and achieved complete remission. Subsequently, she received high-dose chemotherapy with an in vivo rituximab-purged autologous stem cell transplant. Seven years have passed since the transplantation, and she remains in remission. This suggests that transplantation of an in vivo rituximab-purged autograft is a promising strategy for primary bone marrow DLBCL. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1687-9627 1687-9635 |
| Relation: | https://doaj.org/toc/1687-9627; https://doaj.org/toc/1687-9635 |
| DOI: | 10.1155/2012/957063 |
| Access URL: | https://doaj.org/article/ce73eaa5c5e24b59990014b20ab6da2e |
| Accession Number: | edsdoj.73eaa5c5e24b59990014b20ab6da2e |
| Database: | Directory of Open Access Journals |
| ISSN: | 16879627 16879635 |
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| DOI: | 10.1155/2012/957063 |
| Published in: | Case Reports in Medicine |
| Language: | English |