Bibliographic Details
| Title: |
Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease |
| Authors: |
António M. Carvalho da Silva, Cristina Lemos, Henrique B. Silva, Ildete L. Ferreira, Angelo R. Tomé, A. Cristina Rego, Rodrigo A. Cunha |
| Source: |
Frontiers in Aging Neuroscience, Vol 14 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
circadian, Alzheimer’s disease, behavior, LTP, mitochondria, Zeitgeber, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Alzheimer’s disease (AD) is characterized by progressive memory deficits accompanied by synaptic and metabolic deficits, namely of mitochondrial function. AD patients also display a disrupted circadian pattern. Thus, we now compared memory performance, synaptic plasticity, and mitochondria function in 24-week-old non-transgenic (non-Tg) and triple transgenic male mice modeling AD (3xTg-AD) at Zeitgeber 04 (ZT-4, inactive phase) and ZT-16 (active phase). Using the Morris water maze test to minimize the influence of circadian-associated locomotor activity, we observed a circadian variation in hippocampus-dependent learning performance in non-Tg mice, which was impaired in 3xTg-AD mice. 3xTg-AD mice also displayed a lack of circadian variation of their performance in the reversal spatial learning task. Additionally, the amplitude of hippocampal long-term potentiation also exhibited a circadian profile in non-Tg mice, which was not observed in 3xTg-AD mice. Moreover, cerebral cortical synaptosomes of non-Tg mice also displayed a circadian variation of FCCP-stimulated oxygen consumption as well as in mitochondrial calcium retention that were blunted in 3xTg-AD mice. In sum, this multidimensional study shows that the ability to maintain a circadian oscillation in brain behavior, synaptic plasticity, and synaptic mitochondria function are simultaneously impaired in 3xTg-AD mice, highlighting the effects of circadian misalignment in AD. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1663-4365 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnagi.2022.835885/full; https://doaj.org/toc/1663-4365 |
| DOI: |
10.3389/fnagi.2022.835885 |
| Access URL: |
https://doaj.org/article/73e7c39452f548c5aaa57af79ab77433 |
| Accession Number: |
edsdoj.73e7c39452f548c5aaa57af79ab77433 |
| Database: |
Directory of Open Access Journals |
