Academic Journal
The regulatory effect of bromocriptine on cardiac hypertrophy by prolactin and D2 receptor modulation
| Title: | The regulatory effect of bromocriptine on cardiac hypertrophy by prolactin and D2 receptor modulation |
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| Authors: | Karla Aidee Aguayo-Cerón, Claudia Camelia Calzada-Mendoza, Enrique Méndez-Bolaina, Rodrigo Romero-Nava, María Esther Ocharan-Hernández |
| Source: | Clinical and Experimental Hypertension, Vol 42, Iss 7, Pp 675-679 (2020) |
| Publisher Information: | Taylor & Francis Group, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | bromocriptine, cardiac hypertrophy, prlr, d2 r, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | Background Bromocriptine, a dopamine agonist, used for the treatment of hyperprolactinemia, type 2 diabetes, ovarian hyper-stimulation syndrome, has also effects on the cardiac remodeling process, but the mechanism of action is unknown. The aim of this work was to determinate the effect during hypertrophic process through molecular mechanisms that include prolactin receptor (Prlr) and receptor of dopamine 2 (D2 r) expression. Methods We used a model of cardiac hypertrophy induced by an aortocaval fistula (ACF) surgery in rats. Protein concentrations of D2 r and Prlr were determined by western blotting. The treatment consisted in water (control), captopril (50 mg/kg/day), bromocriptine (3 mg/kg/day), and ACF group (n = 6 per group). Results Our results showed that bromocriptine treatment decreases the hypertrophy index. Treatment with bromocriptine increases the protein expression of Prlr and D2 r in the cardiac tissue of rats with cardiac hypertrophy. Conclusions We concluded that bromocriptine has a protective effect on cardiac hypertrophy, and due to this effect, it may modulate the expression of Prlr and D2 r, which are involved in the development of cardiac hypertrophy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1064-1963 1525-6006 10641963 |
| Relation: | https://doaj.org/toc/1064-1963; https://doaj.org/toc/1525-6006 |
| DOI: | 10.1080/10641963.2020.1772814 |
| Access URL: | https://doaj.org/article/edc73e25c1654e75bf0c14c13163241b |
| Accession Number: | edsdoj.73e25c1654e75bf0c14c13163241b |
| Database: | Directory of Open Access Journals |
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| ISSN: | 10641963 15256006 |
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| DOI: | 10.1080/10641963.2020.1772814 |
| Published in: | Clinical and Experimental Hypertension |
| Language: | English |