Bibliographic Details
| Title: |
Evolutionarily Conserved Roles for Apontic in Induction and Subsequent Decline of Cyclin E Expression |
| Authors: |
Xian-Feng Wang, Jin-Xiao Liu, Zhi-Yuan Ma, Yang Shen, Hao-Ran Zhang, Zi-Zhang Zhou, Emiko Suzuki, Qing-Xin Liu, Susumu Hirose |
| Source: |
iScience, Vol 23, Iss 8, Pp 101369- (2020) |
| Publisher Information: |
Elsevier, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Biological Sciences, Molecular Biology, Cell Biology, Science |
| More Details: |
Summary: Cyclin E is a key factor for S phase entry, and deregulation of Cyclin E results in developmental defects and tumors. Therefore, proper cycling of Cyclin E is crucial for normal growth. Here we found that transcription factors Apontic (Apt) and E2f1 cooperate to induce cyclin E in Drosophila. Functional binding motifs of Apt and E2f1 are clustered in the first intron of Drosophila cyclin E and directly contribute to the cyclin E transcription. Knockout of apt and e2f1 together abolished Cyclin E expression. Furthermore, Apt up-regulates Retinoblastoma family protein 1 (Rbf1) for proper chromatin compaction, which is known to repress cyclin E. Notably, Apt-dependent up-regulation of Cyclin E and Rbf1 is evolutionarily conserved in mammalian cells. Our findings reveal a unique mechanism underlying the induction and subsequent decline of Cyclin E expression. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004220305575; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2020.101369 |
| Access URL: |
https://doaj.org/article/73ae7b7dcce94df9a85c2028557a9dee |
| Accession Number: |
edsdoj.73ae7b7dcce94df9a85c2028557a9dee |
| Database: |
Directory of Open Access Journals |
