Bibliographic Details
| Title: |
Protective Effects of Berberis Vulgaris Plant Extract on Paracetamol-induced Liver Toxicity in Rats |
| Authors: |
Serdar Yiğit, Arzu Gezer, Muhammed Yayla, Erdem Toktay, Pınar Aksu Kılıçle, Seyit Ali Bingol, Çığdem Eda Balkan Bozlak |
| Source: |
Van Tıp Dergisi, Vol 29, Iss 4, Pp 428-433 (2022) |
| Publisher Information: |
Van Yuzuncu Yil University, School of Medicine, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
berberis vulgaris, liver, paracetamol, tunel, Medicine |
| More Details: |
INTRODUCTION: Berberis vulgaris extract is known to be protective against many damages due to its anti-inflamatory and antioxidant properties. Paracetamol toxicity is one of the most common toxicities. In our study, we aimed to reduce the damage caused by paracetamol toxicity with the beneficial effects of Berberis vullgaris extract. METHODS: In our study, 42 Sprague Dawley 8-week-old rats were used. 7 groups were formed with 6 female animals in each group. At the 24th hour of the study, all groups underwent laparotomy under anesthesia and liver dissection was performed. Hematoxylin and Eosin (H&E) staining was used to evaluate liver histopathology, and PAS staining was used to show glycogen and basement membrane staining in liver tissue. In addition, scoring was done by showing apoptotic cells with TUNEL stain RESULTS: Hepatic degeneration and peritubular inflammation were quite evident in the groups to which we applied paracetamol. In this study, we observed that the number of positive cells increased in the group given paracetamol in TUNEL staining. As a result of the PAS staining we performed, glycogen accumulation in the hepatocytes of the group we induced with paracetamol was remarkable. DISCUSSION AND CONCLUSION: Berberis vulgaris plant extract appears to reduce Paracetamol-induced hepatic toxicity. As a result of the PAS staining, glycogen accumulation in the hepatocytes was remarkable in the group which was induced with paracetamol. Further studies are required for the use of determined molecules of Berberis vulgaris plant extract against the hepatotoxic effect of paracetamol in paracetamol toxicity. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2587-0351 |
| Relation: |
https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-36675; https://doaj.org/toc/2587-0351 |
| DOI: |
10.5505/vtd.2022.36675 |
| Access URL: |
https://doaj.org/article/73aca073a14449b8b7cdf60e774ace1d |
| Accession Number: |
edsdoj.73aca073a14449b8b7cdf60e774ace1d |
| Database: |
Directory of Open Access Journals |
