Bibliographic Details
| Title: |
Longitudinal HER2 amplification tracked in circulating tumor DNA for therapeutic effect monitoring and prognostic evaluation in patients with breast cancer |
| Authors: |
Xiuwen Guan, Binliang Liu, Yunyun Niu, Xin Dong, Xia Zhu, Chunxiao Li, Lixi Li, Zongbi Yi, Xiaoying Sun, Hongyan Chen, Sijia Lu, Fei Ma |
| Source: |
Breast, Vol 49, Iss , Pp 261-266 (2020) |
| Publisher Information: |
Elsevier, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Breast cancer, ctDNA, HER2 amplification, HER2 copy numbers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstracts: Background: Human epidermal growth factor receptor 2(HER2) status is a crucial predictive factor for prognostic assessment and targeted therapy selection, which may be influenced by intratumor heterogeneity and molecular divergence between the primary site and different metastases. Therefore, we performed a prospective study to confirm the concordance of HER2 amplification in circulating tumor DNA(ctDNA) with primary tumor tissue and verified its clinical implications. Methods: A total of 105 breast cancer patients were enrolled, and dynamic monitoring of HER2 copy numbers in ctDNA was conducted in 31 participants during the treatment. Totally 186 plasma samples were prospectively obtained and blinded to test HER2 copy numbers in ctDNA based on low-coverage whole genome sequencing(WGS) by next-generation sequencing(NGS). Results: Comparing HER2 copy numbers in ctDNA collected before the initiation of next line of anticancer treatment with primary tumor tissue, the concordant rate of HER2 amplification was 86.5%(χ2 = 52.901, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1532-3080 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0960977619312172; https://doaj.org/toc/1532-3080 |
| DOI: |
10.1016/j.breast.2019.12.010 |
| Access URL: |
https://doaj.org/article/ed73735579184da2a63f6eda28adbbf8 |
| Accession Number: |
edsdoj.73735579184da2a63f6eda28adbbf8 |
| Database: |
Directory of Open Access Journals |
