Academic Journal
Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection
| Title: | Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection |
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| Authors: | Kai Luo, Brandilyn A. Peters, Jee-Young Moon, Xiaonan Xue, Zheng Wang, Mykhaylo Usyk, David B. Hanna, Alan L. Landay, Michael F. Schneider, Deborah Gustafson, Kathleen M. Weber, Audrey French, Anjali Sharma, Kathryn Anastos, Tao Wang, Todd Brown, Clary B. Clish, Robert C. Kaplan, Rob Knight, Robert D. Burk, Qibin Qi |
| Source: | Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Genetics |
| Subject Terms: | HIV infection, Diabetes, Gut dysbiosis, Gut metagenome, Inflammatory proteome, Blood metabolome, Medicine, Genetics, QH426-470 |
| More Details: | Abstract Background Gut dysbiosis has been linked with both HIV infection and diabetes, but its interplay with metabolic and inflammatory responses in diabetes, particularly in the context of HIV infection, remains unclear. Methods We first conducted a cross-sectional association analysis to characterize the gut microbial, circulating metabolite, and immune/inflammatory protein features associated with diabetes in up to 493 women (~ 146 with prevalent diabetes with 69.9% HIV +) of the Women’s Interagency HIV Study. Prospective analyses were then conducted to determine associations of identified metabolites with incident diabetes over 12 years of follow-up in 694 participants (391 women from WIHS and 303 men from the Multicenter AIDS Cohort Study; 166 incident cases were recorded) with and without HIV infection. Mediation analyses were conducted to explore whether gut bacteria–diabetes associations are explained by altered metabolites and proteins. Results Seven gut bacterial genera were identified to be associated with diabetes (FDR-q |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1756-994X 38648199 |
| Relation: | https://doaj.org/toc/1756-994X |
| DOI: | 10.1186/s13073-024-01336-1 |
| Access URL: | https://doaj.org/article/ddd735eae386481991401f432e4d62a0 |
| Accession Number: | edsdoj.735eae386481991401f432e4d62a0 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1756994X 38648199 |
|---|---|
| DOI: | 10.1186/s13073-024-01336-1 |
| Published in: | Genome Medicine |
| Language: | English |