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A randomized controlled trial of heterologous ChAdOx1 nCoV-19 and recombinant subunit vaccine MVC-COV1901 against COVID-19

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Title: A randomized controlled trial of heterologous ChAdOx1 nCoV-19 and recombinant subunit vaccine MVC-COV1901 against COVID-19
Authors: Chih-Jung Chen, Lan-Yan Yang, Wei-Yang Chang, Yhu-Chering Huang, Cheng-Hsun Chiu, Shin-Ru Shih, Chung-Guei Huang, Kuan-Ying A. Huang
Source: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Publisher Information: Nature Portfolio, 2022.
Publication Year: 2022
Collection: LCC:Science
Subject Terms: Science
More Details: Public safety concern of the ChAdOx1 vaccine has led to an alternative immunisation strategy against SARS-CoV-2, with this heterologous schedule widely adopted and officially recommended in many countries. Here, the authors report the immunogenicity and safety outcomes of heterologous prime-boost immunisation with ChAdOx1 and a spike-2P subunit vaccine in a single-blinded, randomised trial.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-022-33146-7
Access URL: https://doaj.org/article/734b5924f58149d382b1e865987a8a9d
Accession Number: edsdoj.734b5924f58149d382b1e865987a8a9d
Database: Directory of Open Access Journals
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  Data: <searchLink fieldCode="AR" term="%22Chih-Jung+Chen%22">Chih-Jung Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Lan-Yan+Yang%22">Lan-Yan Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Wei-Yang+Chang%22">Wei-Yang Chang</searchLink><br /><searchLink fieldCode="AR" term="%22Yhu-Chering+Huang%22">Yhu-Chering Huang</searchLink><br /><searchLink fieldCode="AR" term="%22Cheng-Hsun+Chiu%22">Cheng-Hsun Chiu</searchLink><br /><searchLink fieldCode="AR" term="%22Shin-Ru+Shih%22">Shin-Ru Shih</searchLink><br /><searchLink fieldCode="AR" term="%22Chung-Guei+Huang%22">Chung-Guei Huang</searchLink><br /><searchLink fieldCode="AR" term="%22Kuan-Ying+A%2E+Huang%22">Kuan-Ying A. Huang</searchLink>
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  Data: Public safety concern of the ChAdOx1 vaccine has led to an alternative immunisation strategy against SARS-CoV-2, with this heterologous schedule widely adopted and officially recommended in many countries. Here, the authors report the immunogenicity and safety outcomes of heterologous prime-boost immunisation with ChAdOx1 and a spike-2P subunit vaccine in a single-blinded, randomised trial.
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