Bibliographic Details
| Title: |
Total posterior quadrant disconnection for drug‐resistant epilepsy in children |
| Authors: |
Hao Yu, Chang Liu, Yu Sun, Yao Wang, Qingzhu Liu, Taoyun Ji, Shuang Wang, Xiaoyan Liu, Yuwu Jiang, Ye Wu, Lixin Cai |
| Source: |
Epilepsia Open, Vol 9, Iss 6, Pp 2198-2208 (2024) |
| Publisher Information: |
Wiley, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
children, development, drug‐resistant epilepsy, posterior quadrant disconnection, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Abstract Objective To assess seizure outcomes, prognostic factors, and developmental changes in children undergoing total posterior quadrant disconnection (PQD) for drug‐resistant epilepsy (DRE). Methods We conducted a retrospective analysis of the clinical data of children with DRE who underwent total PQD surgery. The study focused on Engel's classification for seizure outcomes, exploring correlation of preoperative data and surgical effectiveness, and predictors of seizure prognosis. It involved a comparative analysis of developmental levels pre‐ and 3 months postoperatively using Griffiths Mental Development Scales‐China (GMDS‐C), and the correlation between clinical characteristics and GMDS‐C results. Results Out of 61 pediatric patients, 70.5% showed no seizure recurrence postoperatively. In the univariate analysis, interictal electroencephalogram (EEG), magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography (FDG‐PET), and acute postoperative seizure (APOS) were significantly related to surgical prognosis. In multivariate analysis, interictal EEG and APOS were identified as predictors of seizure prognosis. Survival analysis indicated significant associations between MRI, interictal EEG, FDG‐PET, APOS and postoperative seizure occurrence. Preoperative GMDS‐C levels were significantly correlated with epilepsy duration, seizure frequency, interictal EEG, and FDG‐PET. GMDS‐C scores improved postoperatively, while developmental quotients remained stable. Significance For patients with structural abnormalities in the entire posterior quadrant, thorough preoperative assessment and timely total PQD surgery can effectively control seizures without causing neurological development deterioration. APOS and interictal EEG abnormalities beyond the posterior quadrant are predictors for seizure prognosis but should not be deemed contraindications for surgery. Plain Language Summary Due to lack of analysis on pediatric total PQD cases, 61 pediatric patients who underwent total PQD surgery were retrospectively enrolled. Seizure and development results were collected and analyzed as dependent variables. The study found that 70.5% of patients were seizure‐free and showed development improvement, with no deaths or severe complications reported. Prognosis predictors included APOS and interictal EEG abnormalities beyond the posterior quadrant. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2470-9239 |
| Relation: |
https://doaj.org/toc/2470-9239 |
| DOI: |
10.1002/epi4.13044 |
| Access URL: |
https://doaj.org/article/7343e7884acd4bc188cf4639977d0057 |
| Accession Number: |
edsdoj.7343e7884acd4bc188cf4639977d0057 |
| Database: |
Directory of Open Access Journals |
