Protoporphyrinogen Oxidase Inhibitor: An Ideal Target for Herbicide Discovery
| Title: | Protoporphyrinogen Oxidase Inhibitor: An Ideal Target for Herbicide Discovery |
|---|---|
| Authors: | Ge-Fei Hao, Yang Zuo, Sheng-Gang Yang, Guang-Fu Yang |
| Source: | CHIMIA, Vol 65, Iss 12 (2011) |
| Publisher Information: | Swiss Chemical Society, 2011. |
| Publication Year: | 2011 |
| Collection: | LCC:Chemistry |
| Subject Terms: | Herbicide, Inhibitor, Molecular design, Protoporphyrinogen oxidase, Qsar, Chemistry, QD1-999 |
| More Details: | As the last common enzyme in the biosynthetic pathway leading to heme and chlorophyll, protoporphyrinogen oxidase (PPO; EC 1.3.3.4) is an ideal target for herbicide development. Currently, about 30 PPO inhibitors have been developed as agricultural herbicides. PPO inhibitors have displayed environmentally benign, but advantageous characteristics, including low toxicity, low effective concentration, broad herbicidal spectrum (active against both monocotyledon and dicotyledon weeds), quick onset of action, and long lasting effect. Over the last several years, great achievements have been made in revealing the structural biology of PPO. Five PPO crystal structures, four isolated in enzyme-inhibitor complexes and one in the native form, have been determined, including those from Nicotiana tabacum, Myxococcus Xanthus, Bacillus subtilis, and human. Although PPO inhibitors have been developed for over forty years, we continue to uncover exciting future prospects for novel PPO-inhibiting herbicides. In this review, we have summarized the structures of PPOs from plants, human, and bacteria; the interactions between PPOs and inhibitors; the quantitative structure–activity relationships of PPO inhibitors; and the molecular design of new PPO inhibitors. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | German English French |
| ISSN: | 0009-4293 2673-2424 |
| Relation: | https://www.chimia.ch/chimia/article/view/5139; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424 |
| DOI: | 10.2533/chimia.2011.961 |
| Access URL: | https://doaj.org/article/aa72f0c259e448c1a5e0b8121ff86b4e |
| Accession Number: | edsdoj.72f0c259e448c1a5e0b8121ff86b4e |
| Database: | Directory of Open Access Journals |
| ISSN: | 00094293 26732424 |
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| DOI: | 10.2533/chimia.2011.961 |
| Published in: | CHIMIA |
| Language: | German English French |