Bibliographic Details
| Title: |
Effect of co-infection with intestinal parasites on COVID-19 severity: A prospective observational cohort study |
| Authors: |
Dawit Wolday, Teklay Gebrecherkos, Zekarias Gessesse Arefaine, Yazezew Kebede Kiros, Atsbeha Gebreegzabher, Geremew Tasew, Mahmud Abdulkader, Hiluf Ebuy Abraha, Abraham Aregay Desta, Ataklti Hailu, Getachew Tollera, Saro Abdella, Masresha Tesema, Ebba Abate, Kidist Lakew Endarge, Tsegaye Gebreyes Hundie, Frehiwot Kassahun Miteku, Britta C. Urban, Henk H.D.F. Schallig, Vanessa C. Harris, Tobias F. Rinke de Wit |
| Source: |
EClinicalMedicine, Vol 39, Iss , Pp 101054- (2021) |
| Publisher Information: |
Elsevier, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
COVID-19, Severity, parasite, africa, co-infection, Medicine (General), R5-920 |
| More Details: |
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a spectrum of clinical presentations. Evidence from Africa indicates that significantly less COVID-19 patients suffer from serious symptoms than in the industrialized world. We and others previously postulated a partial explanation for this phenomenon, being a different, more activated immune system due to parasite infections. Here, we aimed to test this hypothesis by investigating a potential correlation of co-infection with parasites with COVID-19 severity in an endemic area in Africa.Methods: Ethiopian COVID-19 patients were enrolled and screened for intestinal parasites, between July 2020 and March 2021. The primary outcome was the proportion of patients with severe COVID-19. Ordinal logistic regression models were used to estimate the association between parasite infection, and COVID-19 severity. Models were adjusted for sex, age, residence, education level, occupation, body mass index, and comorbidities.Findings: 751 SARS-CoV-2 infected patients were enrolled, of whom 284 (37.8%) had intestinal parasitic infection. Only 27/255 (10.6%) severe COVID-19 patients were co-infected with intestinal parasites, while 257/496 (51.8%) non-severe COVID-19 patients were parasite positive (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-5370 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589537021003345; https://doaj.org/toc/2589-5370 |
| DOI: |
10.1016/j.eclinm.2021.101054 |
| Access URL: |
https://doaj.org/article/729ace971a364b0091028a8750216584 |
| Accession Number: |
edsdoj.729ace971a364b0091028a8750216584 |
| Database: |
Directory of Open Access Journals |
