Academic Journal
A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts
| Title: | A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts |
|---|---|
| Authors: | Maria Carolina Jurcau, Anamaria Jurcau, Razvan Gabriel Diaconu, Vlad Octavian Hogea, Vharoon Sharma Nunkoo |
| Source: | Neurology International, Vol 16, Iss 5, Pp 1039-1065 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Internal medicine LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: | Creutzfeldt-Jakob disease, prions, MRI, PMCA, RT-QuIC, WHO and EUROCJD diagnostic criteria, Medicine, Internal medicine, RC31-1245, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: | Creutzfeldt-Jakob disease is a rare neurodegenerative and invariably fatal disease with a fulminant course once the first clinical symptoms emerge. Its incidence appears to be rising, although the increasing figures may be related to the improved diagnostic tools. Due to the highly variable clinical picture at onset, many specialty physicians should be aware of this disease and refer the patient to a neurologist for complete evaluation. The diagnostic criteria have been changed based on the considerable progress made in research on the pathogenesis and on the identification of reliable biomarkers. Moreover, accumulated knowledge on pathogenesis led to the identification of a series of possible therapeutic targets, although, given the low incidence and very rapid course, the evaluation of safety and efficacy of these therapeutic strategies is challenging. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2035-8377 |
| Relation: | https://www.mdpi.com/2035-8377/16/5/79; https://doaj.org/toc/2035-8377 |
| DOI: | 10.3390/neurolint16050079 |
| Access URL: | https://doaj.org/article/7272defe528b414bac67bdf6dafac377 |
| Accession Number: | edsdoj.7272defe528b414bac67bdf6dafac377 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20358377 |
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| DOI: | 10.3390/neurolint16050079 |
| Published in: | Neurology International |
| Language: | English |