Bibliographic Details
| Title: |
SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell Response |
| Authors: |
Jackson S. Turner, Aaron Day, Wafaa B. Alsoussi, Zhuoming Liu, Jane A. O’Halloran, Rachel M. Presti, Bruce K. Patterson, Sean P. J. Whelan, Ali H. Ellebedy, Philip A. Mudd |
| Source: |
Frontiers in Immunology, Vol 11 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
SARS-CoV-2, COVID-19, cellular immunity, CD8+ T cell, CD4+ T cell, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Prolonged shedding of viral RNA occurs in some individuals following SARS-CoV-2 infection. We perform comprehensive immunologic evaluation of one individual with prolonged shedding. The case subject recovered from severe COVID-19 and tested positive for SARS-CoV-2 viral RNA repeatedly as many as 87 days after the first positive test, 97 days after symptom onset. The subject did not have any associated rise in anti-Spike protein antibody titers or plasma neutralization activity, arguing against re-infection. This index subject exhibited a profoundly diminished circulating CD8+ T cell population and correspondingly low SARS-CoV-2-specific CD8+ T cell responses when compared with a cohort of other recovering COVID-19 subjects. CD4+ T cell responses and neutralizing antibody responses developed as expected in this individual. Our results demonstrate that detectable viral RNA shedding in the upper airway can occur more than 3 months following infection in some individuals with COVID-19 and suggest that impaired CD8+ T cells may play a role in prolonged viral RNA shedding. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.618402/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2020.618402 |
| Access URL: |
https://doaj.org/article/726c86b25c71472686c5fd888af25739 |
| Accession Number: |
edsdoj.726c86b25c71472686c5fd888af25739 |
| Database: |
Directory of Open Access Journals |
