Bibliographic Details
| Title: |
Successful treatment with doxycycline monotherapy for human infection with Babesia venatorum (Babesiidae, Sporozoa) in China: a case report and proposal for a clinical regimen |
| Authors: |
Lei Huang, Yi Sun, Dan-Dan Huo, Ming Xu, Luo-Yuan Xia, Ning Yang, Wei Hong, Lin Huang, Wei-Min Nie, Ru-He Liao, Ming-Zhu Zhang, Dai-Yun Zhu, Yan Li, He-Cheng Ma, Xin Zhang, Yong-Gang Li, Xin-An Huang, Jing-Yuan Wang, Wu-Chun Cao, Fu-Sheng Wang, Jia-Fu Jiang |
| Source: |
Infectious Diseases of Poverty, Vol 12, Iss 1, Pp 1-8 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Infectious and parasitic diseases
LCC:Public aspects of medicine |
| Subject Terms: |
Human babesiosis, Babesia venatorum, Doxycycline monotherapy, China, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| More Details: |
Abstract Background Human babesiosis is a worldwide disease caused by intraerythrocytic protozoa of the genus Babesia. It is transmitted by bites from ixodid ticks, and mechanically transmitted by blood transfusion. It is primarily treated with quinine and/or atovaquone, which are not readily available in China. In this study, we developed a novel treatment regimen involving doxycycline monotherapy in a patient with severe Babesia venatorum infection as an alternative therapeutic medication. The aim of our study is to provide a guidance for clinical practice treatment of human babesiosis. Case presentation A 73-year-old man who had undergone splenectomy and blood transfusion 8 years prior, presented with an unexplained fever, headache, and thrombocytopenia, and was admitted to the Fifth Medical Center of the PLA General Hospital. He was diagnosed with B. venatorum infection by morphological review of thin peripheral blood smears, which was confirmed by multi-gene polymerase chain reaction (PCR), and sequencing of the entire 18s rRNA and partial β-tubulin encoding genes, as well as isolation by animal inoculation. The doxycycline monotherapy regimen (peros, 0.1 g bisindie) was administered following pharmacological guidance and an effective outcome was observed. The patient recovered rapidly following the doxycycline monotherapy. The protozoan load in peripheral blood samples decreased by 88% in hematocrit counts after 8 days, and negative PCR results were obtained after 90 days of follow-up at the hospital. The treatment lasted for 3 months without any side effects or sequelae. The nine-month follow-up survey of the patient did not reveal any signs of recrudescence or anti-babesial tolerance. Conclusions We have reported a clinical case of successful doxycycline monotherapy for human babesiosis caused by B. venatorum, which provides an optional medical intervention for human babesiosis. Graphical Abstract |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2049-9957 |
| Relation: |
https://doaj.org/toc/2049-9957 |
| DOI: |
10.1186/s40249-023-01111-1 |
| Access URL: |
https://doaj.org/article/ac725a42cc3e48bebc8f7cd014e0bd11 |
| Accession Number: |
edsdoj.725a42cc3e48bebc8f7cd014e0bd11 |
| Database: |
Directory of Open Access Journals |
