Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice
| Title: | Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice |
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| Authors: | Mateusz Pieróg, Katarzyna Socała, Elżbieta Wyska, Ewa Poleszak, Piotr Wlaź |
| Source: | Molecules, Vol 26, Iss 16, p 4841 (2021) |
| Publisher Information: | MDPI AG, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Organic chemistry |
| Subject Terms: | ellagic acid, mice, seizure models, pentylenetetrazole, seizure threshold, Organic chemistry, QD241-441 |
| More Details: | Ellagic acid (EA) is a natural dietary polyphenol that has many beneficial properties, including anti-inflammatory, antioxidant, antiviral, antibacterial, and neuroprotective effects. Studies have revealed that EA may modulate seizure activity in chemically induced animal models of seizures. Therefore, the aim of the present study was to investigate the effect of EA on the seizure threshold in two acute seizure tests in male mice, i.e., in the intravenous (i.v.) pentylenetetrazole (PTZ) seizure test and in the maximal electroshock seizure threshold (MEST) test. The obtained results showed that EA (100 mg/kg) significantly elevated the threshold for both the first myoclonic twitch and generalized clonic seizure in the i.v. PTZ seizure test. At the highest dose tested (200 mg/kg), EA increased the threshold for tonic hindlimb extension in the MEST test. EA did not produce any significant changes in motor coordination (assessed in the chimney test) or muscular strength (investigated in the grip-strength test). The plasma and total brain concentration-time profiles of EA after intraperitoneal and oral administration were also determined. Although further studies are necessary to confirm the anticonvulsant activity of EA, our findings suggest that it may modulate seizure susceptibility in animal models. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 26164841 1420-3049 |
| Relation: | https://www.mdpi.com/1420-3049/26/16/4841; https://doaj.org/toc/1420-3049 |
| DOI: | 10.3390/molecules26164841 |
| Access URL: | https://doaj.org/article/7228f5d331df4b79a82fedb328412274 |
| Accession Number: | edsdoj.7228f5d331df4b79a82fedb328412274 |
| Database: | Directory of Open Access Journals |
| ISSN: | 26164841 14203049 |
|---|---|
| DOI: | 10.3390/molecules26164841 |
| Published in: | Molecules |
| Language: | English |