Academic Journal
Increased platelet activation and lower platelet-monocyte aggregates in COVID-19 patients with severe pneumonia.
| Title: | Increased platelet activation and lower platelet-monocyte aggregates in COVID-19 patients with severe pneumonia. |
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| Authors: | Sirada Srihirun, Thanaporn Sriwantana, Sirawat Srichatrapimuk, Pornpun Vivithanaporn, Suppachok Kirdlarp, Somnuek Sungkanuparph, Sithakom Phusanti, Nithita Nanthatanti, Prasit Suwannalert, Nathawut Sibmooh |
| Source: | PLoS ONE, Vol 18, Iss 3, p e0282785 (2023) |
| Publisher Information: | Public Library of Science (PLoS), 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | BackgroundThe increased procoagulant platelets and platelet activation are associated with thrombosis in COVID-19. In this study, we investigated platelet activation in COVID-19 patients and their association with other disease markers.MethodsCOVID-19 patients were classified into three severity groups: no pneumonia, mild-to-moderate pneumonia, and severe pneumonia. The expression of P-selectin and activated glycoprotein (aGP) IIb/IIIa on the platelet surface and platelet-leukocyte aggregates were measured prospectively on admission days 1, 7, and 10 by flow cytometry.ResultsP-selectin expression, platelet-neutrophil, platelet-lymphocyte, and platelet-monocyte aggregates were higher in COVID-19 patients than in uninfected control individuals. In contrast, aGPIIb/IIIa expression was not different between patients and controls. Severe pneumonia patients had lower platelet-monocyte aggregates than patients without pneumonia and patients with mild-to-moderate pneumonia. Platelet-neutrophil and platelet-lymphocyte aggregates were not different among groups. There was no change in platelet-leukocyte aggregates and P-selectin expression on days 1, 7, and 10. aGPIIb/IIIa expression was not different among patient groups. Still, adenosine diphosphate (ADP)-induced aGPIIb/IIIa expression was lower in severe pneumonia than in patients without and with mild-to-moderate pneumonia. Platelet-monocyte aggregates exhibited a weak positive correlation with lymphocyte count and weak negative correlations with interleukin-6, D-dimer, lactate dehydrogenase, and nitrite.ConclusionCOVID-19 patients have higher platelet-leukocyte aggregates and P-selectin expression than controls, indicating increased platelet activation. Compared within patient groups, platelet-monocyte aggregates were lower in severe pneumonia patients. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0282785 |
| Access URL: | https://doaj.org/article/ae721f9559584c04aaab1b95bb1bbbdd |
| Accession Number: | edsdoj.721f9559584c04aaab1b95bb1bbbdd |
| Database: | Directory of Open Access Journals |
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| ISSN: | 19326203 |
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| DOI: | 10.1371/journal.pone.0282785 |
| Published in: | PLoS ONE |
| Language: | English |