Naloxone and Metabolites Quantification in Cord Blood of Prenatally Exposed Newborns and Correlations with Maternal Concentrations
| Title: | Naloxone and Metabolites Quantification in Cord Blood of Prenatally Exposed Newborns and Correlations with Maternal Concentrations |
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| Authors: | Samantha L. Wiegand, Madeleine J. Swortwood, Marilyn A. Huestis, John Thorp, Hendreé E. Jones, Neeta L. Vora |
| Source: | American Journal of Perinatology Reports, Vol 06, Iss 04, Pp e385-e390 (2016) |
| Publisher Information: | Thieme Medical Publishers, Inc., 2016. |
| Publication Year: | 2016 |
| Collection: | LCC:Gynecology and obstetrics |
| Subject Terms: | buprenorphine, naloxone, opioid use disorder, pregnancy, Gynecology and obstetrics, RG1-991 |
| More Details: | Abstract Objective To quantify naloxone and metabolite concentrations in newborns prenatally exposed to sublingual buprenorphine/naloxone and to correlate neonatal and maternal metabolite concentrations. Methods This is a prospective observational cohort study. Eleven pregnant women treated for opioid use disorder with sublingual buprenorphine/naloxone were enrolled. Maternal and newborn blood was collected and analyzed for naloxone, buprenorphine, and metabolites via liquid chromatography tandem mass spectrometry. Descriptive statistics and correlation coefficients were utilized to analyze data. Results Maternal daily naloxone and buprenorphine doses were 1 to 5 mg and 4 to 20 mg, respectively; the mean (standard deviation) time from medication until delivery was 9.9 (4.3) hours. Naloxone was below the limits of quantification (LOQ) in five infants and six mothers with a range of less than LOQ to 0.3 μg/L. There was a strong positive correlation between maternal and newborn naloxone concentrations: Spearman's ρ = 0.89 (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2157-6998 2157-7005 0036-1593 |
| Relation: | https://doaj.org/toc/2157-6998; https://doaj.org/toc/2157-7005 |
| DOI: | 10.1055/s-0036-1593993 |
| Access URL: | https://doaj.org/article/d71f4f1b13e14e8dab7ad9c270cac94b |
| Accession Number: | edsdoj.71f4f1b13e14e8dab7ad9c270cac94b |
| Database: | Directory of Open Access Journals |
| ISSN: | 21576998 21577005 00361593 |
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| DOI: | 10.1055/s-0036-1593993 |
| Published in: | American Journal of Perinatology Reports |
| Language: | English |