Academic Journal
Organ-sparing techniques and dose-volume constrains used in breast cancer radiation therapy – Results from European and Latin American surveys
| Title: | Organ-sparing techniques and dose-volume constrains used in breast cancer radiation therapy – Results from European and Latin American surveys |
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| Authors: | Monica-Emila Chirilă, Fatjona Kraja, Gustavo Nader Marta, Wellington Furtado Pimenta Neves Junior, Gustavo Viani de Arruda, André Guimarães Gouveia, Pierfrancesco Franco, Philip Poortmans, Ivica Ratosa |
| Source: | Clinical and Translational Radiation Oncology, Vol 46, Iss , Pp 100752- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Breast cancer, Radiotherapy, Survey, Organs at risk, Dose volume constraints, Heart sparing, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Background: Advances in local and systemic therapies have improved the outcomes of patients with breast cancer (BC), leading to a possible increased risk for postoperative radiation therapy (RT) late adverse events. The most adequate technologies and dose constraints for organs at risk (OAR) in BC RT have yet to be defined. Methods: An online survey was distributed to radiation oncologists (ROs) practicing in Europe and Latin America including the Caribbean (LAC) through personal contacts, RO and BC professional groups’ networks. Demographic data and clinical practice information were collected. Results: The study included 585 responses from ROs practicing in 57 different countries. The most frequently contoured OAR by European and LAC participants were the whole heart (96.6 % and 97.7 %), the ipsilateral (84.3 % and 90.8 %), and contralateral lung (71.3 % and 77.4 %), whole lung (69.8 % and 72.9 %), and the contralateral breast (66.4 % and. 83.2 %). ESTRO guidelines were preferred in Europe (33.3 %) and the RTOG contouring guideline was the most popular in LAC (62.2 %), while some participants used both recommendations (13.2 % and 19.2 %). IMRT (68.6 % and 59.1 %) and VMAT (65.6 % and 60.2 %) were the preferred modalities used in heart sparing strategies, followed by deep inspiration breath-hold (DIBH) (54.8 % and 37.4 %) and partial breast irradiation (PBI) (41.6 % and 24.6 %). Only a small percentage of all ROs reported the dose-volume constraints for OAR used in routine clinical practice. A mean heart dose (Heart-Dmean) between 4 and 5 Gy was the most frequently reported parameter (17.2 % and 39.3 %). Conclusion: The delineation approaches and sparing techniques for OAR in BC RT vary between ROs worldwide. The low response rate to the dose constraints subset of queries reflects the uncertainty surrounding this topic and supports the need for detailed consensus recommendations in the clinical practice. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-6308 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405630824000296; https://doaj.org/toc/2405-6308 |
| DOI: | 10.1016/j.ctro.2024.100752 |
| Access URL: | https://doaj.org/article/71d953b63e1247f4a1c6e5750c435a76 |
| Accession Number: | edsdoj.71d953b63e1247f4a1c6e5750c435a76 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24056308 |
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| DOI: | 10.1016/j.ctro.2024.100752 |
| Published in: | Clinical and Translational Radiation Oncology |
| Language: | English |