Role of Fenofibrate Use in Dyslipidemia and Related Comorbidities in the Asian Population: A Narrative Review
| Title: | Role of Fenofibrate Use in Dyslipidemia and Related Comorbidities in the Asian Population: A Narrative Review |
|---|---|
| Authors: | Chaicharn Deerochanawong, Sin Gon Kim, Yu-Cheng Chang |
| Source: | Diabetes & Metabolism Journal, Vol 48, Iss 2, Pp 184-195 (2024) |
| Publisher Information: | Korean Diabetes Association, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | asian people, diabetes mellitus, dyslipidemia, fenofibrate, fibric acids, hypertriglyceridemia, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Hypertriglyceridemia and decreased high-density lipoprotein cholesterol (HDL-C) persist despite statin therapy, contributing to residual atherosclerotic cardiovascular disease (ASCVD) risk. Asian subjects are metabolically more susceptible to hypertriglyceridemia than other ethnicities. Fenofibrate regulates hypertriglyceridemia, raises HDL-C levels, and is a recommended treatment for dyslipidemia. However, data on fenofibrate use across different Asian regions are limited. This narrative review summarizes the efficacy and safety data of fenofibrate in Asian subjects with dyslipidemia and related comorbidities (diabetes, metabolic syndrome, diabetic retinopathy, and diabetic nephropathy). Long-term fenofibrate use resulted in fewer cardiovascular (CV) events and reduced the composite of heart failure hospitalizations or CV mortality in type 2 diabetes mellitus. Fenofibrate plays a significant role in improving irisin resistance and microalbuminuria, inhibiting inflammatory responses, and reducing retinopathy incidence. Fenofibrate plus statin combination significantly reduced composite CV events risk in patients with metabolic syndrome and demonstrated decreased triglyceride and increased HDL-C levels with an acceptable safety profile in those with high CV or ASCVD risk. Nevertheless, care is necessary with fenofibrate use due to possible hepatic and renal toxicities in vulnerable individuals. Long-term trials and real-world studies are needed to confirm the clinical benefits of fenofibrate in the heterogeneous Asian population with dyslipidemia. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2233-6079 2233-6087 |
| Relation: | http://e-dmj.org/upload/pdf/dmj-2023-0168.pdf; https://doaj.org/toc/2233-6079; https://doaj.org/toc/2233-6087 |
| DOI: | 10.4093/dmj.2023.0168 |
| Access URL: | https://doaj.org/article/71a78d56ef4a4f1daec7e774e160ab4b |
| Accession Number: | edsdoj.71a78d56ef4a4f1daec7e774e160ab4b |
| Database: | Directory of Open Access Journals |
| ISSN: | 22336079 22336087 |
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| DOI: | 10.4093/dmj.2023.0168 |
| Published in: | Diabetes & Metabolism Journal |
| Language: | English |