Academic Journal
Focal alterations of the callosal area III in primary lateral sclerosis: An MRI planimetry and texture analysis
| Title: | Focal alterations of the callosal area III in primary lateral sclerosis: An MRI planimetry and texture analysis |
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| Authors: | Hans-Peter Müller, Jens Dreyhaupt, Francesco Roselli, Magdalena Schlecht, Albert C. Ludolph, Hans-Jürgen Huppertz, Jan Kassubek |
| Source: | NeuroImage: Clinical, Vol 26, Iss , Pp - (2020) |
| Publisher Information: | Elsevier, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Amyotrophic lateral sclerosis, Corpus callosum, Magnetic resonance imaging, Texture analysis, Motor neuron disease, Primary lateral sclerosis, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Background: The regional distribution of cerebral morphological alterations in primary lateral sclerosis (PLS) is considered to include the area III of the corpus callosum (CC). Objective: The study was designed to investigate regional white matter (WM) alterations in the callosal area III by T1 weighted magnetic resonance imaging (T1w-MRI) data in PLS patients compared with healthy controls, in order to identify atrophy and texture changes in vivo. Methods: T1w-MRI-based white matter mapping was used to perform an operator-independent CC-segmentation for the different areas of the CC in 67 PLS patients vs 82 matched healthy controls and vs 85 ALS patients. The segmentation was followed by texture analysis of the separated CC areas for the PLS patients vs controls and vs ALS patients. Results: PLS was associated with significant atrophy in the area III of the CC (but not in the other callosal segments), while the alterations in the ALS patients were much more variable and were not significant at the group level. Furthermore, significant regional alterations of the texture parameters entropy and homogeneity in this area were shown in PLS patients and in ALS patients. Conclusions: This T1w-MRI study demonstrated focused regional CC atrophy and texture alterations limited to the callosal area III (which comprises fibers projecting into the primary motor cortices) in PLS, in comparison to a higher variability in CC size in ALS. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158220300607; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2020.102223 |
| Access URL: | https://doaj.org/article/7153b2afd19c4171a30db5ba67935199 |
| Accession Number: | edsdoj.7153b2afd19c4171a30db5ba67935199 |
| Database: | Directory of Open Access Journals |
| ISSN: | 22131582 |
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| DOI: | 10.1016/j.nicl.2020.102223 |
| Published in: | NeuroImage: Clinical |
| Language: | English |