Bibliographic Details
| Title: |
Upper Motor Neuron Disorders: Primary Lateral Sclerosis, Upper Motor Neuron Dominant Amyotrophic Lateral Sclerosis, and Hereditary Spastic Paraplegia |
| Authors: |
Timothy Fullam, Jeffrey Statland |
| Source: |
Brain Sciences, Vol 11, Iss 5, p 611 (2021) |
| Publisher Information: |
MDPI AG, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
primary lateral sclerosis, amyotrophic lateral sclerosis, hereditary spastic paraplegia, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Following the exclusion of potentially reversible causes, the differential for those patients presenting with a predominant upper motor neuron syndrome includes primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), or upper motor neuron dominant ALS (UMNdALS). Differentiation of these disorders in the early phases of disease remains challenging. While no single clinical or diagnostic tests is specific, there are several developing biomarkers and neuroimaging technologies which may help distinguish PLS from HSP and UMNdALS. Recent consensus diagnostic criteria and use of evolving technologies will allow more precise delineation of PLS from other upper motor neuron disorders and aid in the targeting of potentially disease-modifying therapeutics. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-3425 |
| Relation: |
https://www.mdpi.com/2076-3425/11/5/611; https://doaj.org/toc/2076-3425 |
| DOI: |
10.3390/brainsci11050611 |
| Access URL: |
https://doaj.org/article/712c3fa82a2c42869f25733888b97527 |
| Accession Number: |
edsdoj.712c3fa82a2c42869f25733888b97527 |
| Database: |
Directory of Open Access Journals |
