Academic Journal
Management of radiation-induced proctitis using submucosal endoscopic injections of autologous adipose-derived stromal vascular fraction: a case report
| Title: | Management of radiation-induced proctitis using submucosal endoscopic injections of autologous adipose-derived stromal vascular fraction: a case report |
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| Authors: | A. V. Smirnov, V. I. Sychev, S. M. Kuznetsova, V. A. Kalsin, V. S. Vasilyev, Yu. V. Ivanov, V. R. Stankevich, D. V. Sazonov, F. G. Zabozlaev, M. A. Konoplyannikov, V. P. Baklaushev, A. V. Troitsky |
| Source: | Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-7 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine (General) LCC:Biochemistry |
| Subject Terms: | Regenerative surgery, Stromal-vascular fraction, Chronic post-radiation proctitis, Mesenchymal stromal cells, Medicine (General), R5-920, Biochemistry, QD415-436 |
| More Details: | Abstract Background Standard approaches to the treatment of chronic post-radiation proctitis are associated with a high risk of complications and a high percentage of unsatisfactory results due to the reduced regenerative potential of irradiated tissues. Regenerative surgery techniques using the stromal-vascular cell fraction (SVF) based on the patient’s autologous adipose tissue are a promising direction for study. Clinical case description A 76-year-old patient suffering from chronic post-radiation erosive-ulcerative proctitis, grade 4 according to RTOG–EORTC, complicated by recurrent profuse rectal bleeding, underwent local autotransplantation of SVF into the submucosal layer of the rectum and pararectal connective tissue. The follow-up colonoscopies 1 and 6 months after the surgery and histological examination showed the complete epithelialization of ulcerative defects and a decrease in proctitis activity. There were no bleeding episodes during the 12-month postoperative observation period. Conclusion The proangiogenic, wound-healing, and anti-apoptotic effects of the SVF cell suspension provided reduction of inflammation activity, epithelialization of ulcers, and elimination of defecation-associated hemorrhage, following the SVF injection into the submucosal layer of the rectal wall and pararectal connective tissue in a patient with post-radiation proctitis with ulcers and recurrent bleeding. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1757-6512 |
| Relation: | https://doaj.org/toc/1757-6512 |
| DOI: | 10.1186/s13287-024-04017-3 |
| Access URL: | https://doaj.org/article/711c493d71ac486c8bc1c8498ea5815f |
| Accession Number: | edsdoj.711c493d71ac486c8bc1c8498ea5815f |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17576512 |
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| DOI: | 10.1186/s13287-024-04017-3 |
| Published in: | Stem Cell Research & Therapy |
| Language: | English |