Academic Journal
The third dose of measles-containing vaccine induces robust immune responses against measles in young seronegative healthcare workers who had previous two-dose measles vaccination
| Title: | The third dose of measles-containing vaccine induces robust immune responses against measles in young seronegative healthcare workers who had previous two-dose measles vaccination |
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| Authors: | Yong Chan Kim, Heejin Nam, Jun Yong Choi, Eui-Cheol Shin, Young Hwa Choi |
| Source: | Journal of Infection and Public Health, Vol 16, Iss 10, Pp 1643-1649 (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Infectious and parasitic diseases LCC:Public aspects of medicine |
| Subject Terms: | Measles, Seroprevalence, Measles vaccine, Immunogenicity, Safety, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| More Details: | Background: Despite the low measles antibody positivity rate among young healthcare workers (HCWs) who have previously received two doses of a measles-containing vaccine (MCV), whether an additional dose of MCV acts as a booster remains unknown. Thus, we aimed to evaluate the immune responses to a third dose of MCV in young HCWs. Methods: Hospital-wide measles seroprevalence was assessed using enzyme-linked immunosorbent assay (ELISA). The immunogenicity of a third dose of MCV was determined in young seronegative HCWs (born between 1986 and 1997) who had previously received a two-dose measles vaccination. Results: A total of 3033 (92.6%) HCWs had anti-measles immunoglobulin G. The lowest seropositivity rate was observed in HCWs aged 20–24 years (87.7%). In this group, HCWs who received a third dose of MCV had higher seropositivity than those who received a second dose (89.5% vs. 75.4%). A third dose of MCV was administered to 18 HCWs who did not have anti-measles IgG despite two doses. Neutralizing antibody titers increased significantly 4 weeks after the third vaccination. Although neutralizing antibody titers decreased 1 year post vaccination, 17 (94.4%) HCWs had medium (121–900 mIU/mL) or high (>900 mIU/mL) levels. Furthermore, the third dose of MCV increased the measles virus-specific T-cell effector function. Conclusions: The third dose of MCV induced a strong immune response against measles in young seronegative HCWs who had previously received a two-dose measles vaccination. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1876-0341 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1876034123002599; https://doaj.org/toc/1876-0341 |
| DOI: | 10.1016/j.jiph.2023.08.002 |
| Access URL: | https://doaj.org/article/a70f9c985d074a308ba7ee160b3fa45b |
| Accession Number: | edsdoj.70f9c985d074a308ba7ee160b3fa45b |
| Database: | Directory of Open Access Journals |
| ISSN: | 18760341 |
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| DOI: | 10.1016/j.jiph.2023.08.002 |
| Published in: | Journal of Infection and Public Health |
| Language: | English |