Bibliographic Details
| Title: |
Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp. |
| Authors: |
Yeon-Ju Lee, Su Hyun Kim, Hansol Choi, Hyi-Seung Lee, Jong Seok Lee, Hee Jae Shin, Jihoon Lee |
| Source: |
Molecules, Vol 24, Iss 5, p 840 (2019) |
| Publisher Information: |
MDPI AG, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Organic chemistry |
| Subject Terms: |
Scalarispongia, sesterterpenoid, furan, pyrrole, conjugate addition, cytotoxicity, Organic chemistry, QD241-441 |
| More Details: |
Three furan-containing scalarane sesterterpenoids (1⁻3) and a novel pyrrole-containing analog (4) were isolated from the sponge Scalarispongia species. Compound 3, reported in the literature as a synthetic derivative of furoscalarol 2, was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives (5, 6) were obtained from the unintended reaction of 2. The isolated natural products 3 and 4 and the artifact 5 showed moderate to high cytotoxicity against six human cancer cell lines, whereas compound 6, the C-16 epimer of 5, showed no cytotoxicity at a concentration of 60 μΜ. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/24/5/840; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules24050840 |
| Access URL: |
https://doaj.org/article/70538c123cbd4c35bbc8e9fd1f2f8b9e |
| Accession Number: |
edsdoj.70538c123cbd4c35bbc8e9fd1f2f8b9e |
| Database: |
Directory of Open Access Journals |
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