Bibliographic Details
| Title: |
Diagnostic accuracy and clinical usefulness of erythrocyte creatine content to predict the improvement of anaemia in patients receiving maintenance haemodialysis |
| Authors: |
Ohki Hayashi, Seishi Nakamura, Tetsuro Sugiura, Shun Hasegawa, Yoshiaki Tsuka, Nobuyuki Takahashi, Sanae Kikuchi, Koichiro Matsumura, Toshika Okumiya, Masato Baden, Ichiro Shiojima |
| Source: |
BMC Nephrology, Vol 24, Iss 1, Pp 1-9 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: |
Erythrocyte creatine content, Erythropoiesis stimulating agent, Erythropoietin resistance, Haemodialysis, Renal anaemia, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: |
Abstract Background The improvement of anaemia over time by erythropoiesis stimulating agent (ESA) is associated with better survival in haemodialysis patients. We previously reported that erythrocyte creatine content, a marker of erythropoietic capacity, was a reliable marker to estimate the effectiveness of ESA. The aim of this study was to examine the accuracy and clinical usefulness of erythrocyte creatine content to predict the improvement of anaemia in haemodialysis patients. Methods ESA dose was fixed 3 months prior to the enrollment and was maintained throughout the study period. Erythrocyte creatine content and haematologic indices were measured at baseline in 92 patients receiving maintenance haemodialysis. Haemoglobin was also measured 3 months after. Improvement of anaemia was defined as ≥ 0.8 g/dL change in haemoglobin from baseline to 3 months. Results Erythrocyte creatine content was significantly higher in 32 patients with improvement of anaemia compared to 60 patients with no improvement of anaemia (2.47 ± 0.74 vs. 1.57 ± 0.49 μmol/gHb, P = 0.0001). When 9 variables (erythrocyte creatine content, ESA dose, reticulocyte, haptoglobin, haemoglobin at baseline, serum calcium, intact parathyroid hormone, transferrin saturation and serum ferritin) were used in the multivariate logistic regression analysis, erythrocyte creatine emerged as the most important variable associated with the improvement of anaemia (P = 0.0001). The optimal cut-off point of erythrocyte creatine content to detect the improvement of anaemia was 1.78 μmol/gHb (Area under the curve: 0.86). Sensitivity and specificity of erythrocyte creatine content to detect the improvement of anaemia were 90.6% and 83.3%. Conclusion Erythrocyte creatine content is a reliable marker to predict the improvement of anaemia 3 months ahead in patients receiving maintenance haemodialysis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2369 |
| Relation: |
https://doaj.org/toc/1471-2369 |
| DOI: |
10.1186/s12882-022-03055-4 |
| Access URL: |
https://doaj.org/article/6feceb4db1534476b48b69f9c048d595 |
| Accession Number: |
edsdoj.6feceb4db1534476b48b69f9c048d595 |
| Database: |
Directory of Open Access Journals |
