Bibliographic Details
| Title: |
Hematopoietic Effects of Angelica gigas Nakai Extract on Cyclophosphamide-Induced Myelosuppression |
| Authors: |
Mincheol Kang, Seojin Park, Yuseong Chung, Je-Oh Lim, Jae Seon Kang, Jun Hong Park |
| Source: |
Plants, Vol 11, Iss 24, p 3476 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Botany |
| Subject Terms: |
Angelica gigas Nakai, myelosuppression, cyclophosphamide, hematopoiesis, Botany, QK1-989 |
| More Details: |
Myelosuppression is a major adverse effect of chemotherapy. With the increasing number of cancer patients worldwide, there is a growing interest in therapeutic approaches that reduce the adverse effects of chemotherapy. Angelica gigas Nakai (AGN) roots have been widely used in oriental medicine to treat blood-related diseases, including cancer. However, the effects of AGN on myelosuppression have not been studied. Here, we investigated the effects of AGN ethanol extract (AGNEX) on cyclophosphamide-induced myelosuppression. AGNEX treatment significantly decreased white blood cell levels while increasing red blood cell and platelet levels in the peripheral blood. It inhibited thymus and spleen atrophy. It also enhanced serum levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α. qRT-PCR results showed that AGNEX decreased the expression of IL-1b and stem cell factor (SCF) in the bone marrow (BM) while increasing the mRNA expression of IL-3 and IL-6 in the spleen. Although AGNEX did not significantly decrease apoptosis and cell cycle arrest in the BM and splenocytes, AGNEX plays a positive role in cyclophosphamide-induced myelosuppression. AGNEX administration increased BM cells in the femur while decreasing apoptotic BM cells. These findings suggest that AGNEX could be used to treat myelosuppression and as a combination therapy in cancer patients. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2223-7747 |
| Relation: |
https://www.mdpi.com/2223-7747/11/24/3476; https://doaj.org/toc/2223-7747 |
| DOI: |
10.3390/plants11243476 |
| Access URL: |
https://doaj.org/article/6fca9999e008405f8d83ad3e14c9a31e |
| Accession Number: |
edsdoj.6fca9999e008405f8d83ad3e14c9a31e |
| Database: |
Directory of Open Access Journals |
