Frequency of γδ T Cells and Invariant Natural Killer T Cells in Helicobacter Pylori-infected Patients with Peptic Ulcer and Gastric Cancer
| Title: | Frequency of γδ T Cells and Invariant Natural Killer T Cells in Helicobacter Pylori-infected Patients with Peptic Ulcer and Gastric Cancer |
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| Authors: | Mojtaba Shadman, Zeinab Rajabian, Abolghasem Ajami, Hadi Hussein-Nattaj, Alireza Rafiei, Vahid Hosseini, Tarang Taghvaei, Ali Abbasi, Mohsen Tehrani |
| Source: | Iranian Journal of Allergy, Asthma and Immunology, Vol 14, Iss 5 (2015) |
| Publisher Information: | Tehran University of Medical Sciences, 2015. |
| Publication Year: | 2015 |
| Collection: | LCC:Medicine |
| Subject Terms: | Antigen, Helicobacter pylori, Invariant Natural Killer T Cells, Peptic Ulcer, Receptor, Stomach Neoplasms, Medicine |
| More Details: | To clarify the effect of γδ T cells and invariant Natural Killer T (iNKT) cells in pathophysiology of dyspeptic disorders, number of these two cells in patients with non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), and gastric cancer (GC) were compared.Patients with dyspepsia were divided into three groups of NUD, PUD, and GC according to their endoscopic and histopathological examinations. Helicobacter pylori infection was diagnosed by rapid urease test and histopathology. The number of peripheral blood CD3+TCRgd+ T cells and CD3+Va24Ja18+ iNKT cells were determined by flow cytometry. Immunohistochemistry (IHC) was also used for identifying the TCRgd+ cells.Forty two patients with NUD (31.6%), 44 with PUD (33.1%), and 47 with GC (35.3%) were included in the study. The frequency of CD3+TCRgd+ T cells in peripheral blood of patients with GC (2.71±0.25) was significantly lower than that in NUD (3.97±0.32, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1735-1502 1735-5249 |
| Relation: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/599; https://doaj.org/toc/1735-1502; https://doaj.org/toc/1735-5249 |
| Access URL: | https://doaj.org/article/6f641b268d434a878f0c84604e6838b1 |
| Accession Number: | edsdoj.6f641b268d434a878f0c84604e6838b1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 17351502 17355249 |
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| Published in: | Iranian Journal of Allergy, Asthma and Immunology |
| Language: | English |