| Title: |
Assessment of the antibacterial effect of Khaya senegalensis on some Gram-negative bacteria |
| Authors: |
Victorien Dougnon, Edna Hounsa, Hornel Koudokpon, Eric Agbodjento, Anny Afaton, Kevin Sintondji, Jean Robert Klotoe, Julien Segbo, Lamine Baba-Moussa |
| Source: |
Bulletin of the National Research Centre, Vol 45, Iss 1, Pp 1-8 (2021) |
| Publisher Information: |
SpringerOpen, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Science |
| Subject Terms: |
Khaya senegalensis, Mode of action, Antibacterial activity, Gram-negative Bacteria, Science |
| More Details: |
Abstract Background The matter of antimicrobial resistance evokes the urgency to explore alternatives to the antibiotics traditionally used for microbial infections. This study aimed to elucidate the mechanism of action of the antibacterial effect of Khaya senegalensis liable for bacterial strains responsible for diarrheal infections. Results The data collected indicate that the bacterial strains tested (Salmonella Typhimurium ATCC 14028, Escherichia coli ATCC 25922, Shigella spp. and Salmonella spp.) were sensitive to the extracts of Khaya senegalensis (Desr.) A.Juss. (aqueous and hydro-ethanol) to varying degrees. The hydro-ethanolic extract was active on all strains with a MIC of 25 mg/mL coupled with a bactericidal effect. The aqueous extract was only active on the Salmonella spp. strain. Membrane permeability test data show that Khaya senegalensis extracts affect the bacterial strains tested by attacking the stability of their outer membrane. This potential indicated by the high percentage of membrane destabilization of the bacteria is significantly (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2522-8307 |
| Relation: |
https://doaj.org/toc/2522-8307 |
| DOI: |
10.1186/s42269-021-00568-0 |
| Access URL: |
https://doaj.org/article/e6f2fbd10e654f698c2765fe823c11cb |
| Accession Number: |
edsdoj.6f2fbd10e654f698c2765fe823c11cb |
| Database: |
Directory of Open Access Journals |
