Bibliographic Details
| Title: |
A potential immunotherapy target for breast cancer: parenchymal and immune-stromal expression of the NLRP3 inflammasome pathway |
| Authors: |
Qian-mei Zhu, Hui-xian Li, Pei-qing Ma, Lin-xin Wu, Tai-hang Wang, Wen-bin Li, Lin Zhang, Xue Yang, Xiangyi Kong, Yu-lin Sun, Tao Yan |
| Source: |
BMC Cancer, Vol 23, Iss 1, Pp 1-17 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
NLRP3 inflammasome, Innate immune system, Caspase-1, ASC, Breast cancer, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Background The NOD-, LRR- and pyrin domain‑containing 3 (NLRP3) inflammasome is a critical component of the innate immune system. It has been known to play an important role in the carcinogenesis and prognosis of breast cancer patients. While the clinical evidence of the relationship between NLRP3 inflammasome activation and long-term survival is still limited, the possible roles of parenchymal or immune-stromal cells of breast cancer tissues in contributing to such carcinogenesis and progression still need to be clarified. This study is an analysis of patients receiving breast cancer surgery in a previous clinical trial. Methods Immunohistochemistry (IHC) was used to detect the expression levels of NLRP3 inflammasome pathway-related proteins, including NLRP3, caspase-1, apoptosis-associated speck-like protein (ASC), IL-1β, and IL-18, in parenchymal and immune-stromal cells of breast cancer tissues compared to those of adjacent normal tissues, respectively. The relationship between NLRP3 inflammasome expression and clinicopathological characteristics, as well as 5-year survivals were analyzed using the Chi-square test, Kaplan–Meier survival curves, and Cox regression analysis. Results In the parenchymal cells, ASC and IL-18 protein levels were significantly up-regulated in breast cancer tissues compared with adjacent normal tissues (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2407 |
| Relation: |
https://doaj.org/toc/1471-2407 |
| DOI: |
10.1186/s12885-023-11609-4 |
| Access URL: |
https://doaj.org/article/6f05d5d73d374ce0abd751cb3c2b7c51 |
| Accession Number: |
edsdoj.6f05d5d73d374ce0abd751cb3c2b7c51 |
| Database: |
Directory of Open Access Journals |
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